Mori A, Sato T, Lee P, Furuuchi M, Tazaki H, Katayama K, Mizutani H, Sako T, Arai T
Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180-8602, Japan.
Vet Res Commun. 2009 Jun;33(5):439-51. doi: 10.1007/s11259-008-9190-3. Epub 2008 Dec 13.
Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However, the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly, plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs.
循环中的单糖水平可反映全身葡萄糖/能量代谢情况。在糖尿病和其他代谢紊乱患者中可以观察到这些水平的特征性变化。已有一些报告描述了甘露糖代谢在生理和病理条件下作为能量来源的重要性。然而，犬类中甘露糖的循环水平与糖尿病病理生理学之间的关系尚不清楚。本研究检测了健康对照犬和糖尿病犬的循环甘露糖水平，并评估了犬类甘露糖水平的临床意义。与正常健康对照犬相比，糖尿病犬的循环甘露糖水平更高。血浆甘露糖分别与血浆葡萄糖和果糖胺呈正相关。有趣的是，血浆甘露糖水平受血浆胰岛素水平影响。在进食和葡萄糖耐量试验中，血浆甘露糖水平对循环胰岛素水平的变化有反应。尽管观察到胰岛素水平存在差异，但在对照动物和糖尿病动物进食后，循环血浆甘露糖水平均下降。然而，当进行葡萄糖耐量试验时，观察到甘露糖水平与胰岛素水平呈正相关。因此，通过葡萄糖耐量试验获得的血浆甘露糖水平可作为评估糖尿病犬胰岛素抵抗或缺乏的一种新的诊断方法。
