一组老年人血液单核细胞（BMNC）的增殖反应：淋巴细胞表型和细胞因子产生的作用。
Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine production.
作者信息
Bruunsgaard H, Pedersen A N, Schroll M, Skinhøj P, Pedersen B K
机构信息
Department of Infectious Diseases, H:S, Rigshospitalet, University of Copenhagen, Denmark.
出版信息
Clin Exp Immunol. 2000 Mar;119(3):433-40. doi: 10.1046/j.1365-2249.2000.01146.x.
Abstract
Age-related impaired T cell function is associated with increased mortality risk. The purpose of the present study was therefore to identify factors associated with the age-related decreased phytohaemagglutinin (PHA)-induced proliferative response of lymphocytes in a cohort of 174 81-year-old humans and in 91 young controls. Decreased proliferation was associated with a reduced number of true naive CD4+ cells (CD62L+CD45RO-). Furthermore, a low IL-2-stimulated proliferation was correlated with a decreased PHA response in the elderly cohort, whereas reciprocal interactions of IL-10- and IL-2-producing cells were of importance in both elderly and young subjects. Accordingly, a minimum of true naive CD4+ cells was required for a normal proliferative response to PHA, perhaps by providing sufficient IL-2 which is critical for growth of naive as well as memory cells.
摘要
与年龄相关的T细胞功能受损与死亡风险增加相关。因此，本研究的目的是在174名81岁的人群队列和91名年轻对照中，确定与年龄相关的淋巴细胞对植物血凝素（PHA）诱导的增殖反应降低相关的因素。增殖减少与真正的初始CD4+细胞（CD62L+CD45RO-）数量减少有关。此外，在老年人群队列中，低IL-2刺激的增殖与PHA反应降低相关，而产生IL-10和IL-2的细胞之间的相互作用在老年和年轻受试者中均很重要。因此，对PHA的正常增殖反应可能需要最少数量的真正初始CD4+细胞来提供足够的IL-2，而IL-2对初始细胞和记忆细胞的生长至关重要。
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