Bánóczy J, Csiba A
Oral Surg Oral Med Oral Pathol. 1976 Dec;42(6):766-74. doi: 10.1016/0030-4220(76)90099-2.
The histologic material of 500 leukoplakia patients was analyzed in order to define the characteristics of epithelial dysplasia and to correlate the findings with the clinical data. Epithelial dysplasia was found in 120 cases (24 per cent) and was graded as mild, moderate, or severe. The occurrence of dysplasia was highest in the group of erosive leukoplakias. The majority of the severe dysplasias were found on the tongue and lips. Follow-up studies on sixty-eight leukoplakia patients with histologic dysplasia revealed carcinoma in nine cases (13.2 per cent) during the mean observation period of 6.3 years. Leukoplakias of the tongue showed the highest incidence of malignant change.
为了明确上皮发育异常的特征并将研究结果与临床数据相关联，对500例白斑患者的组织学材料进行了分析。在120例（24%）患者中发现了上皮发育异常，并将其分为轻度、中度或重度。发育异常在糜烂性白斑组中发生率最高。大多数重度发育异常见于舌和唇。对68例有组织学发育异常的白斑患者进行的随访研究显示，在平均6.3年的观察期内，有9例（13.2%）发生了癌变。舌部白斑的恶变发生率最高。
