Li Z, Li F X, Byrd D, Deyhle G M, Sesser D E, Skeels M R, Lamm S H
Epidemiology and Occupational Health, Inc., Washington, DC 20007, USA.
J Occup Environ Med. 2000 Feb;42(2):200-5. doi: 10.1097/00043764-200002000-00020.
Environmental contamination of drinking water has been observed for perchlorate, a chemical able to affect thyroid function. This study examines whether that exposure affected the thyroid function of newborns. Neonatal blood thyroxine (T4) levels for days 1 to 4 of life were compared for newborns from the city of Las Vegas, Nevada, which has perchlorate in its drinking water, and those from the city of Reno, Nevada, which does not (detection limit, 4 micrograms/L [ppb]). This study is based on blood T4 analyses from more than 23,000 newborns in these two cities during the period April 1998 through June 1999. No difference was found in the mean blood T4 levels of the newborns from these two cities. Drinking water perchlorate levels measured monthly for Las Vegas ranged during this study period from non-detectable for 8 months to levels of 9 to 15 ppb for 7 months. Temporal differences in mean T4 level were noted in both cities but were unrelated to the perchlorate exposure. This study was sufficiently sensitive to detect the effects of gender, birth weight, and the day of life on which the blood sample was taken on the neonatal T4 level, but it detected no effect from environmental exposures to perchlorate that ranged up to 15 micrograms/L (ppb).
人们已经观察到饮用水受到高氯酸盐的环境污染，高氯酸盐是一种能够影响甲状腺功能的化学物质。本研究调查了这种暴露是否会影响新生儿的甲状腺功能。对来自内华达州拉斯维加斯市（其饮用水中含有高氯酸盐）和内华达州里诺市（其饮用水中不含高氯酸盐，检测限为4微克/升[ppb]）的新生儿出生后第1至4天的新生儿血液甲状腺素（T4）水平进行了比较。本研究基于1998年4月至1999年6月期间这两个城市23000多名新生儿的血液T4分析。这两个城市新生儿的平均血液T4水平没有差异。在本研究期间，拉斯维加斯每月测量的饮用水高氯酸盐水平从8个月检测不到到7个月的9至15 ppb不等。两个城市都注意到平均T4水平的时间差异，但与高氯酸盐暴露无关。本研究足够灵敏，能够检测到性别、出生体重以及采血日对新生儿T4水平的影响，但未检测到高达15微克/升（ppb）的环境高氯酸盐暴露产生的影响。
