Ozawa S, Imai Y, Suwa T, Kitajima M
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Recent Results Cancer Res. 2000;155:73-87.
An endoluminal surface coil: Esophageal cancer was studied by high resolution magnetic resonance imaging (MRI) to determine the histopathologic basis for signal intensity in these lesions and to determine the potential of this modality for evaluating the depth of cancer invasion. In a basic study, 14 tumors were examined with a 1.5-T superconductive MR system using a surface coil. The esophageal wall could be differentiated into four layers on the T1-weighted images and seven layers on the T2-weighted images. The signal intensity of the tumor varied from low to intermediate on the T1- and T2-weighted images. The submucosal layer is important in evaluating cancer invasion on the T2-weighted images. In a clinical study, 30 patients with esophageal cancer were examined with a 1.5-T superconductive MR system using an endoluminal surface coil. In terms of depth of cancer invasion, the accuracy rate of MRI using the endoluminal surface coil was 83%. In conclusion, MRI with an endoluminal surface coil will be a useful examination for esophageal cancer in the future. Antibody-coated magnetite particles: A highly specific and effective MRI contrast agent was prepared by coating superparamagnetite particles with monoclonal antibodies (MAbs) directed against epidermal growth factor receptors (EGFRs), which are overexpressed in esophageal squamous cell carcinoma. The agent was shown to have EGFR-specific MRI contrast capacity in vivo in athymic rats bearing TE8 or H69 tumors. Immunospecific MRI using magnetite particles coated with MAbs against EGFR seems to be useful in the diagnosis of squamous cell carcinoma of the esophagus.
通过高分辨率磁共振成像（MRI）研究食管癌，以确定这些病变信号强度的组织病理学基础，并确定这种检查方式评估癌症浸润深度的潜力。在一项基础研究中，使用表面线圈，通过1.5-T超导磁共振系统对14个肿瘤进行了检查。在T1加权图像上食管壁可分为四层，在T2加权图像上可分为七层。肿瘤在T1加权和T2加权图像上的信号强度从低到中等不等。在T2加权图像上评估癌症浸润时，黏膜下层很重要。在一项临床研究中，使用腔内表面线圈，通过1.5-T超导磁共振系统对30例食管癌患者进行了检查。就癌症浸润深度而言，使用腔内表面线圈的MRI准确率为83%。总之，未来腔内表面线圈MRI将是一种用于食管癌的有用检查方法。抗体包被的磁铁矿颗粒：通过用针对表皮生长因子受体（EGFR）的单克隆抗体（MAb）包被超顺磁性磁铁矿颗粒，制备了一种高度特异性和有效的MRI造影剂，EGFR在食管鳞状细胞癌中过度表达。在携带TE8或H69肿瘤的无胸腺大鼠体内，该造影剂显示出具有EGFR特异性MRI造影能力。使用针对EGFR的MAb包被的磁铁矿颗粒进行免疫特异性MRI似乎对食管鳞状细胞癌的诊断有用。
