Bernet-Bernady P, Preux P M, Preux C, Dumas M, Vallat J M, Couratier P
Service de Neurologie CHU de Limoges, Faculté de Médecine.
Rev Neurol (Paris). 2000 Jan;156(1):41-6.
European Database Multiple Sclerosis (EDMUS) is a standardized tool which allows the collection of clinical, biological, radiological and therapeutic data on multiple sclerosis (MS). A descriptive analysis of 199 patients was done using EDMUS (version 2.2). Most data agreed with previous published results, except a low 0.4 sex ratio. At the beginning of MS, 42 p. 100 of MS patients developed pyramidal and sensory involvements and 14 p. 100 retrobulbar optic neuritis. Optic neuritis was the most frequent initial symptom of relapsing-remitting MS (25.9 p. 100) but not in the chronic progressive form (5.5 p, 100; p < 0.01). Surprisingly, relapsing-remitting form occurred more frequently whereas the secondary progressive form was diagnosed less. The concordances between the three disability scales, EGS (EDMUS Grading Scale), EDSS (Expanded Disability Status Score) and AI (Hauser Ambulation Index) were correct. In clinical practice, EDMUS is user-friendly and rapid. The lack of radiological data and the necessary quantification of only one disability scale, EGS may be too restrictive. The analysis of most of clinical data is possible by using integrated selection within the software, but sometimes needs more complex procedures.
欧洲多发性硬化症数据库（EDMUS）是一种标准化工具，可用于收集多发性硬化症（MS）的临床、生物学、放射学和治疗数据。使用EDMUS（2.2版）对199例患者进行了描述性分析。除了性别比例低至0.4外，大多数数据与先前发表的结果一致。在MS发病初期，42%的MS患者出现锥体束和感觉受累，14%出现球后视神经炎。视神经炎是复发缓解型MS最常见的初始症状（25.9%），但在慢性进展型中并非如此（5.5%；p<0.01）。令人惊讶的是，复发缓解型更为常见，而继发进展型的诊断较少。三种残疾量表，即EGS（EDMUS分级量表）、EDSS（扩展残疾状态评分）和AI（豪泽步行指数）之间的一致性是正确的。在临床实践中，EDMUS用户友好且快速。缺乏放射学数据以及仅对一种残疾量表EGS进行必要的量化可能过于受限。通过使用软件中的综合选择可以对大多数临床数据进行分析，但有时需要更复杂的程序。
