Flachenecker P, Hartung H P
Klinische Forschungsgruppe für Multiple Sklerose, Neurologische Klinik und Poliklinik, Julius-Maximilians-Universität, Würzburg.
Nervenarzt. 1996 Apr;67(4):277-82.
EDMUS, the European Database for Multiple Sclerosis (MS), was established on the occasion of the first European Concerted Action for MS under the auspices of the European Community. The system is user-friendly and makes it possible to record and retrieve data relevant to MS. Within the framework of another European Concerted Action, several international multicenter trials are currently in progress. EVALUED, a validation of the EDMUS system, assesses the interrater variability; PRIMS examines the influence of pregnancy and the post-partum period on the course of MS; and PRESTIMUS investigates predictive factors in suspected MS. Further, planned studies include ERAZMUS (early azathioprine and interferon-beta treatment in MS) and AZASTOP, which is designed to evaluate the effect of stopping azathioprine treatment.
欧洲多发性硬化症数据库(EDMUS)是在欧洲共同体主持下的首个欧洲多发性硬化症联合行动之际建立的。该系统用户友好,能够记录和检索与多发性硬化症相关的数据。在另一项欧洲联合行动的框架内,目前正在进行多项国际多中心试验。EDMUS系统验证项目EVALUED评估评估者间的变异性;PRIMS研究怀孕和产后时期对多发性硬化症病程的影响;PRESTIMUS调查疑似多发性硬化症的预测因素。此外,计划开展的研究包括ERAZMUS(多发性硬化症的早期硫唑嘌呤和β-干扰素治疗)和AZASTOP,后者旨在评估停止硫唑嘌呤治疗的效果。