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[性周期不同阶段对大鼠在十字迷宫中行为的影响]

[The effect of different stages of the sex cycle on rat behavior in a plus maze].

作者信息

Vinogradova E P

机构信息

Department of Higher Nervous Activity and Psychophysiology, St.-Petersburg State University.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Nov-Dec;49(6):1039-45.

PMID:10693284
Abstract

Anxiety and motor activity of female white rats in the elevated plus-maze were studied at different stages of the reproduction cycle (estrus, diestrus, pregnancy and lactation). The level of anxiety was lower, and that of locomotor and exploratory activity was higher during estrus and lactation than during diestrus and pregnancy. Exposure to chronic pain of threshold intensity did not induce behavioral changes in pregnant rats. There was no difference between the control and experimental animals in the level of plasma corticosterone.

摘要

在繁殖周期的不同阶段(发情期、间情期、孕期和哺乳期),研究了高架十字迷宫中雌性白鼠的焦虑和运动活动情况。发情期和哺乳期的焦虑水平较低,而运动和探索活动水平高于间情期和孕期。暴露于阈强度的慢性疼痛未在怀孕大鼠中引起行为变化。对照动物和实验动物的血浆皮质酮水平没有差异。

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Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Nov-Dec;49(6):1039-45.
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Estradiol decreases anxiety behavior and enhances inhibitory avoidance and gestational stress produces opposite effects.雌二醇可降低焦虑行为,并增强抑制性回避,而孕期应激则产生相反的效果。
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Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats.雌激素对于向腹侧被盖区注入5α-孕烷-3α-醇-20-酮(3α,5α-四氢孕酮)以促进去卵巢大鼠的社交和性行为是必需的,但对其探索行为和情感行为则并非如此。
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Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors.抑制处于行为发情期大鼠海马体中的孕酮代谢会降低抗焦虑行为,并增强探索行为和抗伤害感受行为。
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