Salomé Nicolas, Landgraf Rainer, Viltart Odile
Unité de Neurosciences et de Physiologie adaptatives, Equipe Stress Périnatal, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
Behav Neurosci. 2006 Jun;120(3):719-23. doi: 10.1037/0735-7044.120.3.719.
Exposure to the open arm of the elevated-plus maze was used to assess the neurobiological correlates of anxiety in the high-anxiety-related behavior (HAB) and low-anxiety-related behavior (LAB) rat lines. The authors sought to determine whether this mild stressor could be considered a valuable anxiety test revealing specific behavioral differences. Behavioral parameters scored were submitted to a discriminant and factor analysis to investigate emotional parameters discriminating HAB and LAB rats. Principal component analysis showed that the HAB rats' behavior was driven by anxiety, whereas the LAB rats' behavior was mainly explained by locomotor activity. Moreover, the rats displayed behaviors that reflected distinct coping strategies confirming anxiogenic open arm effects and differential appraisals of the stressor dependent on the genetic predisposition to either hyper- or hypo-anxiety.
利用高架十字迷宫的开放臂暴露实验，评估高焦虑相关行为（HAB）和低焦虑相关行为（LAB）大鼠品系中焦虑的神经生物学相关性。作者试图确定这种轻度应激源是否可被视为一种能揭示特定行为差异的有价值的焦虑测试。对所记录的行为参数进行判别分析和因子分析，以研究区分HAB和LAB大鼠的情绪参数。主成分分析表明，HAB大鼠的行为由焦虑驱动，而LAB大鼠的行为主要由运动活动来解释。此外，这些大鼠表现出反映不同应对策略的行为，证实了开放臂的致焦虑效应以及取决于高焦虑或低焦虑遗传易感性的对应激源的不同评估。
