Soden M, Vasudevan H, Roberts B, Coelen R, Hamlin G, Vasudevan S, La Brooy J
University of Queensland, Townsville, Australia.
Arthritis Rheum. 2000 Feb;43(2):365-9. doi: 10.1002/1529-0131(200002)43:2<365::AID-ANR16>3.0.CO;2-E.
To document the histology of Ross River virus (RRV) arthritis and to examine inflamed synovium for viral RNA.
Biopsy tissue from the inflamed knees of 12 patients with RRV infection was studied using conventional and immunostaining techniques. Reverse transcriptase-polymerase chain reaction technology was used to probe for the presence of viral RNA in the synovial biopsy samples and in serum.
Hyperplasia of the synovial lining layer, vascular proliferation, and mononuclear cell infiltration were the main histologic changes. RRV RNA was found in knee biopsy tissue that was obtained from 2 patients at 5 weeks after the onset of symptoms.
RRV RNA was identified in inflamed synovium more than a month after symptoms began. Inflammation was apparent in the absence of detectable virus in the majority of patients.
记录罗斯河病毒（RRV）关节炎的组织学特征，并检测发炎滑膜中的病毒RNA。
采用传统和免疫染色技术，对12例RRV感染患者发炎膝关节的活检组织进行研究。运用逆转录聚合酶链反应技术，检测滑膜活检样本和血清中病毒RNA的存在情况。
滑膜衬里层增生、血管增殖和单核细胞浸润是主要的组织学变化。在症状出现5周后，从2例患者的膝关节活检组织中发现了RRV RNA。
症状开始一个多月后，在发炎的滑膜中鉴定出RRV RNA。大多数患者在未检测到病毒的情况下炎症明显。
