从英国腹泻病暴发中分离出的肠聚集性大肠杆菌的特性分析。
Characterization of enteroaggregative Escherichia coli isolated from outbreaks of diarrhoeal disease in England.
作者信息
Spencer J, Smith H R, Chart H
机构信息
Laboratory of Enteric Pathogens, Central Public Health Laboratory, London.
出版信息
Epidemiol Infect. 1999 Dec;123(3):413-21. doi: 10.1017/s0950268899002976.
Twenty-two strains of enteroaggregative Escherichia coli (EAggEC), isolated from four outbreaks of diarrhoeal disease in England, were examined for a range of phenotypic attributes including the ability to produce fimbriae, haemolysins and siderophores, and cell-surface properties such as surface charge and hydrophobicity. Strains of EAggEC isolated from two of these outbreaks belonged to a diverse range of serotypes and were heterogeneous in phenotype. Strains of EAggEC isolated from the other two outbreaks belonged predominantly to serotypes 086:H34 and 098:H-, respectively. Only two strains expressed fimbriae and two strains produced an 18 kDa membrane associated protein (MAP), suggesting that EAggEC express a range of adhesion mechanisms to produce the cell arrangement recognized as the 'stacked brick' formation. The possible explanation for the diversity of EAggEC serotypes is discussed.
从英国4起腹泻病暴发中分离出22株肠集聚性大肠杆菌（EAggEC），对其一系列表型特征进行了检测，包括产生菌毛、溶血素和铁载体的能力，以及诸如表面电荷和疏水性等细胞表面特性。从其中2起暴发中分离出的EAggEC菌株属于多种血清型，且表型各异。从另外2起暴发中分离出的EAggEC菌株则分别主要属于086:H34和098:H-血清型。只有2株表达菌毛，2株产生一种18 kDa的膜相关蛋白（MAP），这表明EAggEC表达一系列黏附机制以形成被认为是“堆叠砖”状的细胞排列。文中讨论了EAggEC血清型多样性的可能原因。
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