Green B L, Krupnick J L, Rowland J H, Epstein S A, Stockton P, Spertus I, Stern N
Department of Psychiatry, Georgetown University, Washington, DC, USA.
J Clin Oncol. 2000 Mar;18(5):1084-93. doi: 10.1200/JCO.2000.18.5.1084.
To identify predictors of psychiatric problems in women with early-stage breast cancer.
One hundred sixty women with early-stage breast cancer were recruited from three treatment centers. They filled out self-report questionnaires, including a medical history and demographic survey, the Trauma History Questionnaire, Life Event Questionnaire, Brief Symptom Inventory, Beck Depression Inventory, and Duke-UNC Functional Social Support Questionnaire, and were evaluated using the Structured Clinical Interview for DSM-III-R.
Hierarchical regression analyses indicated that four of five variable sets made a significant incremental contribution to outcome prediction, with 35% to 37% of the variance explained. Outcomes were predicted by demographic variables, trauma history variables, precancer psychiatric diagnosis, recent life events, and perceived social support. Cancer treatment variables did not predict outcome.
The findings highlight the important roles of trauma history and recent life events in adjustment to cancer and have implications for screening and treatment.
确定早期乳腺癌女性精神问题的预测因素。
从三个治疗中心招募了160名早期乳腺癌女性。她们填写了自我报告问卷，包括病史和人口统计学调查、创伤史问卷、生活事件问卷、简明症状量表、贝克抑郁量表和杜克大学-北卡罗来纳大学功能性社会支持问卷，并使用《精神疾病诊断与统计手册》第三版修订本的结构化临床访谈进行评估。
分层回归分析表明，五个变量集中的四个对结果预测有显著的增量贡献，解释了35%至37%的方差。结果由人口统计学变量、创伤史变量、癌症前精神诊断、近期生活事件和感知到的社会支持预测。癌症治疗变量不能预测结果。
研究结果突出了创伤史和近期生活事件在适应癌症方面的重要作用，并对筛查和治疗有启示意义。
