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腺瘤性结肠息肉病蛋白

The adenomatous polyposis coli protein.

作者信息

Näthke I S

机构信息

Department of Anatomy and Physiology, University of Dundee, UK.

出版信息

Mol Pathol. 1999 Aug;52(4):169-73. doi: 10.1136/mp.52.4.169.

DOI:10.1136/mp.52.4.169
PMID:10694935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC395695/
Abstract

Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.

摘要

腺瘤性结肠息肉病（APC）基因的突变与大多数结直肠癌相关。APC蛋白与肿瘤发展的许多方面有关。本文将讨论最近的数据，这些数据表明APC可能在细胞中具有多种功能。首先，APC是Wnt信号通路的一个组成部分；其次，APC可能在细胞迁移中发挥作用；最后，APC可能调节细胞增殖和凋亡。

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The adenomatous polyposis coli protein.腺瘤性结肠息肉病蛋白
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A role for the Adenomatous Polyposis Coli protein in chromosome segregation.腺瘤性结肠息肉病蛋白在染色体分离中的作用。
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Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy.肾母细胞瘤中腺瘤性结肠息肉病（APC）基因的微卫星分析及β连环蛋白的免疫表达：一项纳入83例接受术前化疗患者的研究
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EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability.EB1蛋白调节微管动力学、细胞极性和染色体稳定性。
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本文引用的文献

1
Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability.糖原合酶激酶-3β对Wnt信号负调节因子axin的磷酸化作用可调节其稳定性。
J Biol Chem. 1999 Apr 16;274(16):10681-4. doi: 10.1074/jbc.274.16.10681.
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Cellular mechanisms of wingless/Wnt signal transduction.
Curr Top Dev Biol. 1999;43:153-90. doi: 10.1016/s0070-2153(08)60381-6.
3
Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer.β-连环蛋白和桥粒芯蛋白在黏附、信号传导及癌症中的差异分子相互作用
Curr Opin Cell Biol. 1998 Oct;10(5):629-39. doi: 10.1016/s0955-0674(98)80039-2.
4
beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.β-TrCP是非洲爪蟾胚胎中Wnt/β-连环蛋白信号通路和背轴形成的负调节因子。
Mech Dev. 1998 Sep;77(1):75-80. doi: 10.1016/s0925-4773(98)00134-8.
5
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.轴抑制蛋白（Axin）是一种Wnt信号通路抑制剂，可与β-连环蛋白、糖原合成酶激酶3β（GSK-3β）和腺瘤性息肉病蛋白（APC）相互作用，并降低β-连环蛋白水平。
Genes Cells. 1998 Jun;3(6):395-403. doi: 10.1046/j.1365-2443.1998.00198.x.
6
The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.腺瘤性结肠息肉病结合蛋白EB1与细胞质微管和纺锤体微管相关。
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10596-601. doi: 10.1073/pnas.95.18.10596.
7
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.缺乏Tcf-4的小鼠小肠上皮干细胞区室的耗竭。
Nat Genet. 1998 Aug;19(4):379-83. doi: 10.1038/1270.
8
Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin.LEF-1对Wnt-1信号的响应及与β-连环蛋白的关联对转录调控的调节作用
Mol Cell Biol. 1998 Aug;18(8):4807-18. doi: 10.1128/MCB.18.8.4807.
9
Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.果蝇APC对犰狳蛋白的调控在视网膜发育过程中抑制神经元凋亡。
Cell. 1998 Jun 26;93(7):1171-82. doi: 10.1016/s0092-8674(00)81461-0.
10
A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.
Eur J Biochem. 1998 May 1;253(3):591-7. doi: 10.1046/j.1432-1327.1998.2530591.x.