Mazumdar A, Verma G R, Bose S M, Ganguly N K
Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Trop Gastroenterol. 1999 Jul-Sep;20(3):107-10.
Carcinoembryonic antigen (CEA) assay was performed in 40 patients of histologically proven colorectal carcinoma. The overall incidence of positivity was 72.5%. The incidence increased from 40% in Duke's A stage to 84.6% in Duke's C stage. Similarly the mean CEa levels also increased as the disease advanced i.e. 4.96 ng/ml, 8.07 ng/ml and 12.7 ng/ml in Duke's A, B and C respectively. Cancer with poor prognosis i.e. poorly differentiated and colloid carcinoma, had significantly less rise in CEA values (P < 0.05) as compared to well differentiated carcinoma. There was no relation of CEA values with the gross appearance of the tumour and lymph node involvement. CEA level came down in all the patients after surgery. Based on the postoperative CEA estimation, complete tumour clearance had been achieved in 86.2% of patients.
对40例经组织学证实的结肠直肠癌患者进行了癌胚抗原（CEA）检测。阳性总发生率为72.5%。发生率从杜克A期的40%增至杜克C期的84.6%。同样，随着疾病进展，CEA平均水平也升高，即杜克A期、B期和C期分别为4.96 ng/ml、8.07 ng/ml和12.7 ng/ml。预后较差的癌症，即低分化癌和胶样癌，与高分化癌相比，CEA值升高明显较少（P<0.05）。CEA值与肿瘤大体外观及淋巴结受累情况无关。所有患者术后CEA水平均下降。根据术后CEA评估，86.2%的患者实现了肿瘤完全清除。
