Caldas M, Dhillon R
Department of Paediatric Cardiology, Royal Brompton Hospital, London, United Kingdom.
Cardiol Young. 2000 Jan;10(1):46-8. doi: 10.1017/s1047951100006375.
The incidence of congenital heart disease is higher in monozygotic than dizygotic twins, with a higher concordance rate. Although coarctation of the aorta has previously been reported in monozygotic twins, to the best of our knowledge it has not been described in dizygotic twins. We report here such a concurrence in dizygotic twins conceived by in-vitro fertilisation. The finding provides support for both genetic and environmental factors in the aetiology of congenital heart disease. Furthermore, it highlights our lack of data regarding the outcome of in-vitro fertilisation.
单卵双胞胎先天性心脏病的发病率高于双卵双胞胎，且一致性率更高。虽然此前已有单卵双胞胎发生主动脉缩窄的报道，但据我们所知，双卵双胞胎中尚未有相关描述。我们在此报告一对通过体外受精孕育的双卵双胞胎同时发生该病的情况。这一发现为先天性心脏病病因中的遗传和环境因素均提供了支持。此外，它还凸显了我们在体外受精结局方面缺乏数据的问题。
