Abo M, Liang J, Qian L, Chen J D
Lynn Institute for Healthcare Research, Oklahoma City, Oklahoma 73112, USA.
Dig Dis Sci. 2000 Jan;45(1):129-35. doi: 10.1023/a:1005425814046.
The aims of this study were to investigate the effect of duodenal distension on intestinal myoelectrical activity and to investigate whether intestinal pacing was able to reverse the effects of distension. Six female hound dogs with four pairs of electrodes on the proximal jejunum were involved in this study. The protocol consisted of 30 min of recording of jejunal myoelectrical activity as baseline and 90 min of recording during distension. Intestinal pacing was performed during the second 30 min of distension. Duodenal distension severely impaired intestinal myoelectrical activity. The percentage of normal slow waves was reduced from 90.8+/-8.4% at baseline to 73.8+/-10.2%, 57.2+/-11.4%, and 53.7+/-16.0% during the first, second and third 30 min of distension (P<0.05, ANOVA). The dominant power was similarly decreased and the minute-by-minute variation of dominant frequency was significantly increased after distension. Intestinal pacing reversed distension-induced dysrhythmia. The percentage of normal slow waves during the 30 min of distension with pacing was significantly higher than the corresponding 30 min of distension without pacing (88.5+/-6.6% vs. 57.2+/-11.4%, P<0.03). It was concluded that intestinal pacing can normalize distension-induced dysrhythmia and has a potential as a future therapeutic modality for intestinal motor disorders.
本研究的目的是调查十二指肠扩张对肠道肌电活动的影响，并研究肠道起搏是否能够逆转扩张的影响。本研究纳入了6只在空肠近端放置了四对电极的雌性猎犬。实验方案包括记录30分钟的空肠肌电活动作为基线，以及在扩张期间记录90分钟。在扩张的第二个30分钟内进行肠道起搏。十二指肠扩张严重损害了肠道肌电活动。正常慢波的百分比从基线时的90.8±8.4%降至扩张的第一个、第二个和第三个30分钟时的73.8±10.2%、57.2±11.4%和53.7±16.0%（方差分析，P<0.05）。优势功率同样降低，扩张后优势频率的逐分钟变化显著增加。肠道起搏逆转了扩张引起的心律失常。在有起搏的30分钟扩张期间，正常慢波的百分比显著高于无起搏的相应30分钟扩张期间（88.5±6.6%对57.2±11.4%，P<0.03）。得出的结论是，肠道起搏可使扩张引起的心律失常正常化，并且作为未来肠道运动障碍的治疗方式具有潜力。
