Xu Xiaohong, Chen J D Z
Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA.
Dig Dis Sci. 2006 Apr;51(4):671-6. doi: 10.1007/s10620-006-3190-3.
Previous studies have shown that sildenafil inhibits the esophageal motility in both humans and animals. The aim of this study was to investigate the effects of sildenafil on intestinal myoelectrical activity and motility. The study was composed of 2 experiments and performed in 7 healthy female dogs with a duodenal cannula 20 cm beyond pylorus (19-26 kg). The first experiment was designed to study the effects of sildenafil on intestinal myoelectrical activity and it included 2 sessions each consisting of 30-minute baseline, 15-minute posttreatment (placebo or 100 mg sildenafil) and 90 minutes after a liquid meal. Intestinal myoelectrical activity was recorded during the entire experiment period. The second experiment was aimed to investigate the effect of sildenafil on intestinal motility and was performed immediately after a solid meal. Intestinal motility was measured by a manometric catheter inserted into the small intestine via the duodenum cannula for 30 minutes at baseline and 60 minutes after sildenafil. Sildenafil significantly reduced the amplitude but had no effect on the frequency and regularity of the intestinal myoelectrical activity. Sildenafil significantly inhibited postprandial intestinal contractions. Although the frequency of the contractions was not altered, the mean area under the curve was significantly reduced during the first 30 minutes (P < .03) and second 30 minutes after sildenafil (P < .03); the power of intestinal contractile activities was also significantly reduced during the first 30 minutes (P < .0004) and second 30 minutes after sildenafil (P < .0003) in comparison with baseline. In conclusion, sildenafil inhibits the amplitude of both intestinal contractile activity and intestinal slow waves.
先前的研究表明，西地那非可抑制人和动物的食管动力。本研究的目的是探讨西地那非对肠道肌电活动和动力的影响。该研究由2个实验组成，在7只健康的雌性犬中进行，这些犬在幽门以远20 cm处（19 - 26 kg）置有十二指肠插管。第一个实验旨在研究西地那非对肠道肌电活动的影响，包括2个时段，每个时段包括30分钟的基线期、15分钟的治疗后（安慰剂或100 mg西地那非）以及流食餐后90分钟。在整个实验期间记录肠道肌电活动。第二个实验旨在研究西地那非对肠道动力的影响，在固体餐后立即进行。通过经十二指肠插管插入小肠的测压导管在基线期测量30分钟以及在给予西地那非后60分钟测量肠道动力。西地那非显著降低了肠道肌电活动的幅度，但对频率和规律性没有影响。西地那非显著抑制餐后肠道收缩。虽然收缩频率未改变，但与基线相比，在给予西地那非后的前30分钟（P < 0.03）和第二个30分钟（P < 0.03），曲线下平均面积显著减小；在给予西地那非后的前30分钟（P < 0.0004）和第二个30分钟（P < 0.0003），肠道收缩活动的强度也与基线相比显著降低。总之，西地那非抑制肠道收缩活动和肠道慢波的幅度。
