Dombrowski A, Jenkins R, Raghoobar S, Bills G, Polishook J, Peláez F, Burgess B, Zhao A, Huang L, Zhang Y, Goetz M
Merck Research Laboratories, Rahway, NJ 07065, USA.
J Antibiot (Tokyo). 1999 Dec;52(12):1077-85. doi: 10.7164/antibiotics.52.1077.
During the course of our screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors of MEK kinase. Comparative and empirical studies of fermentation conditions improved the titers of the compounds of interest. Striking changes in the ratios and amounts of the major and minor compounds in some cases were achieved by manipulations of media composition.
在我们对真菌天然产物的筛选过程中，发现几种培养物的提取物能产生一系列相关的间苯二酚内酯化合物，这些化合物是MEK激酶的有效抑制剂。通过对发酵条件的比较和实证研究，提高了目标化合物的产量。在某些情况下，通过调整培养基成分，主要和次要化合物的比例及含量发生了显著变化。
