Link H, Huang Y M, Xiao B G
Karolinska Institute, Division of Neurology, Huddinge University Hospital, Stockholm, Sweden.
J Neuroimmunol. 1999 Dec;100(1-2):102-10. doi: 10.1016/s0165-5728(99)00197-6.
The mechanisms by which autoimmune diseases are triggered and by which the activation of autoreactive T cells is initiated and maintained are not yet fully understood. As the most potent antigen presenting cells (APC), and also being responsible for antigen transport as well as primary sensitisation of T cells, dendritic cells (DC) are capable of breaking the state of self-ignorance and inducing aggressive autoreactive T cells. In the development of autoimmune diseases, different types of DC exhibit distinct properties for inducing Th1/Th2 cell responses. Appropriate cytokines can convert immunogenic DC to tolerogenic DC. Utilizing the possibility to promote the tolerogenic effects of DC, a new therapeutic tool might soon become available to treat multiple sclerosis and other autoimmune diseases.
自身免疫性疾病的触发机制以及自身反应性T细胞的激活和维持机制尚未完全明确。作为最强大的抗原呈递细胞（APC），并且负责抗原转运以及T细胞的初次致敏，树突状细胞（DC）能够打破自身免疫忽视状态并诱导具有攻击性的自身反应性T细胞。在自身免疫性疾病的发展过程中，不同类型的DC在诱导Th1/Th2细胞反应方面表现出不同特性。适当的细胞因子可将免疫原性DC转化为耐受性DC。利用促进DC耐受性效应的可能性，一种新的治疗工具可能很快就会用于治疗多发性硬化症和其他自身免疫性疾病。
