马来西亚半岛东海岸急性病毒性肝炎病例的四年回顾（1994 - 1997年）

A four year review of acute viral hepatitis cases in the east coast of peninsular Malaysia (1994-1997).

作者信息

Saat Z, Sinniah M, Kin T L, Baharuddin R, Krishnasamy M

机构信息

Virology Division, Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.

出版信息

Southeast Asian J Trop Med Public Health. 1999 Mar;30(1):106-9.

PMID:10695797

Abstract

A total of 1,157 sera from jaundiced patients with clinical and biochemical evidence of liver disease received from government hospital in Kelantan and Terengganu, during the period from 1994 to 1997, were investigated to determine the cause. Hepatitis A virus was found to be the main cause in 26.1% (24/92) of symptomatic clinical hepatitis cases in 1994, 47.8% (63/132) in 1995, 66.4% (613/923) in 1996 and 20% (2/10) in 1997. Sera received in 1996 were also tested for hepatitis B, hepatitis C, hepatitis D and hepatitis E. 1.4% (13/923) anti-bodies were found to be positive for HBc IgM indicating recent HBV infection, 5.4% (50/923) for total HCV Ab, 0.9% (8/923) for total HDV Ab and 0.4% (4/923) for anti-HEV IgM. This study shows that HAV is still a major problem in Kelantan and Terengganu, and there is a need to identify effective strategies for prevention and control in these two states.

摘要

1994年至1997年期间，从吉兰丹和丁加奴的政府医院收集了1157份来自有肝病临床和生化证据的黄疸患者的血清，以确定病因。结果发现，甲型肝炎病毒是1994年有症状的临床肝炎病例中26.1%（24/92）的主要病因，1995年为47.8%（63/132），1996年为66.4%（613/923），1997年为20%（2/10）。1996年收到的血清还检测了乙型肝炎、丙型肝炎、丁型肝炎和戊型肝炎。结果发现，1.4%（13/923）的抗HBc IgM抗体呈阳性，表明近期感染了乙肝病毒；5.4%（50/923）的抗HCV总抗体呈阳性；0.9%（8/923）的抗HDV总抗体呈阳性；0.4%（4/923）的抗HEV IgM呈阳性。这项研究表明，甲型肝炎病毒在吉兰丹和丁加奴仍然是一个主要问题，有必要在这两个州确定有效的预防和控制策略。