Teo Esmeralda Chi-Yuan, Tan Boon-Huan, Purdy Michael A, Wong Pui-San, Ting Pei-Jun, Chang Pik-Eu Jason, Oon Lynette Lin-Ean, Sue Amanda, Teo Chong-Gee, Tan Chee-Kiat
Department of Haematology, Singapore General Hospital, Singapore.
DSO National Laboratories, Singapore.
Am J Trop Med Hyg. 2017 Apr;96(4):922-928. doi: 10.4269/ajtmh.16-0482. Epub 2017 Jan 16.
AbstractThe incidence of hepatitis E in Singapore appears to be increasing. A retrospective case-series study of patients diagnosed with hepatitis E in a tertiary hospital from 2009 to 2013 was conducted. Of 16 cases, eight (50%) were solid-organ transplant recipients (SOTRs), and 14 (88%) were found infected by genotype 3 hepatitis E virus (HEV-3). Bayesian inferences based on HEV subgenomic sequences from seven cases suggest that HEV-3 strains were introduced to Singapore as two principal lineages. Within limitations of the study, it can be inferred that one lineage, in the 3efg clade, emerged about 83 years ago, probably originating from Japan, whereas the other, in the 3abchij clade, emerged about 40 years ago, from the United States. Establishment and subsequent transmissions of strains from these two lineages likely contribute to the current endemicity of hepatitis E in Singapore.
新加坡戊型肝炎的发病率似乎在上升。对2009年至2013年在一家三级医院被诊断为戊型肝炎的患者进行了一项回顾性病例系列研究。在16例病例中，8例（50%）为实体器官移植受者（SOTR），14例（88%）被发现感染了3型戊型肝炎病毒（HEV-3）。基于7例病例的戊型肝炎病毒亚基因组序列的贝叶斯推断表明，HEV-3毒株作为两个主要谱系被引入新加坡。在该研究的局限性范围内，可以推断，一个谱系在3efg分支中，大约在83年前出现，可能起源于日本，而另一个谱系在3abchij分支中，大约在40年前出现，来自美国。这两个谱系毒株的建立和随后的传播可能导致了新加坡目前戊型肝炎的地方性流行。
