Garrett S, Adams D F, Bogle G, Donly K, Drisko C H, Hallmon W W, Hancock E B, Hanes P, Hawley C E, Johnson L, Kiger R, Killoy W, Mellonig J T, Raab F J, Ryder M, Stoller N, Polson A, Wang H L, Wolinsky L E, Yukna R A, Harrold C Q, Hill M, Johnson V B, Soouthard G L
Atrix Laboratories, Inc, Fort Collins, CO 80525-4417, USA.
J Periodontol. 2000 Jan;71(1):22-30. doi: 10.1902/jop.2000.71.1.22.
This research report evaluates clinical changes resulting from local delivery of doxycycline hyclate (DH) or traditional scaling and root planing (SRP) in a group of patients undergoing supportive periodontal therapy (SPT).
In all, 141 patients received either DH (67) or SRP (74) treatment in sites > or =5 mm on one-half of their dentition at baseline and month 4.
Clinical results were determined at month 9. Baseline mean probing depth recordings were similar between the two groups (DH = 5.9 mm; SRP = 5.9 mm). Mean month 9 results showed similar clinical results for attachment level gain (DH 0.7 mm; SRP 0.8 mm) and probing depth reduction (DH 1.3 mm; SRP 1.1 mm). Percentage of sites showing > or =2 mm attachment level gain at month 9 was 24.7% in the DH group and 21.2% in the SRP group. Thirty-nine percent (39%) of DH sites and 38% of SRP sites showed > or =2 mm probing depth reduction. When treated sides of the dentition were compared to untreated sides, DH showed a difference in disease activity (> or =2 mm attachment loss) from 19.3% (untreated) to 7.2% (treated); and SRP from 14.3% (untreated) to 8.1% (treated).
Results show that both DH without concomitant mechanical instrumentation and SRP were equally effective as SPT in this patient group over the 9-month study period.
本研究报告评估了在一组接受支持性牙周治疗（SPT）的患者中，局部应用盐酸多西环素（DH）或传统龈下刮治术和根面平整术（SRP）所导致的临床变化。
共有141例患者在基线期和第4个月时，在其牙列一侧≥5mm的部位接受了DH治疗（67例）或SRP治疗（74例）。
在第9个月时确定临床结果。两组的基线平均探诊深度记录相似（DH = 5.9mm；SRP = 5.9mm）。第9个月的平均结果显示，在附着水平增加（DH为0.7mm；SRP为0.8mm）和探诊深度减少（DH为1.3mm；SRP为1.1mm）方面，临床结果相似。在第9个月时，附着水平增加≥2mm的部位百分比在DH组中为24.7%，在SRP组中为21.2%。39%的DH部位和38%的SRP部位探诊深度减少≥2mm。当将牙列的治疗侧与未治疗侧进行比较时，DH显示疾病活动度（≥2mm附着丧失）从19.3%（未治疗）降至7.2%（治疗）；SRP则从14.3%（未治疗）降至8.1%（治疗）。
结果表明，在为期9个月的研究期间，对于该患者组，不伴有机械器械操作的DH和SRP作为SPT同样有效。
