Javali Mukhatar Ahmed, Vandana K L
Department of Periodontics, Al Badar Rural Dental College and Hospital, Gulbarga, Karnataka, India.
J Indian Soc Periodontol. 2012 Jan;16(1):43-8. doi: 10.4103/0972-124X.94603.
Local delivery of antimicrobial has resulted in good clinical outcome along with scaling and root planing. The present study is carried out to evaluate and compare the efficacy of local delivery of 10% doxycycline hyclate in adjunct to scaling and root planing in the treatment of periodontitis.
A randomized crossover split mouth design was performed, a total number of 130 sites from 4 patients, 63 sites from patients with aggressive periodontitis and 67 sites from chronic periodontitis patients were selected and divided into scaling and root planing (SRP) group, SRP and doxycycline group and doxycycline alone group. Clinical parameters viz. plaque index, modified gingival index, bleeding index, clinical attachment level (CAL), and sub gingival temperature were evaluated on day 0, 15(th), 45(th), and 90(th) day. CAL recording was performed only on day 0 and 90(th) day.
In 90 days study, all the three groups showed significant reduction in clinical parameters. But on comparison, SRP and doxycycline group showed better results than doxycycline alone group and SRP alone group.
The results of this study demonstrated that doxycycline hyclate 10% gel (Atridox) is as effective as SRP in reducing the clinical signs of periodontitis.
在进行龈下刮治及根面平整术的同时局部应用抗菌药物已取得了良好的临床效果。本研究旨在评估和比较在治疗牙周炎时，局部应用10%盐酸多西环素辅助龈下刮治及根面平整术的疗效。
采用随机交叉双盲设计，选取4例患者共130个位点，其中侵袭性牙周炎患者63个位点，慢性牙周炎患者67个位点，并分为龈下刮治及根面平整术（SRP）组、SRP联合多西环素组和单纯多西环素组。在第0、15、45和90天评估临床参数，即菌斑指数、改良牙龈指数、出血指数、临床附着水平（CAL）和龈下温度。仅在第0天和第90天记录CAL。
在90天的研究中，所有三组的临床参数均显著降低。但相比之下，SRP联合多西环素组的效果优于单纯多西环素组和单纯SRP组。
本研究结果表明，10%盐酸多西环素凝胶（Atridox）在减轻牙周炎临床症状方面与SRP效果相当。
