同一受试者局部应用环丙沙星和氧氟沙星后的房水浓度。
Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects.
作者信息
Cekiç O, Batman C, Totan Y, Yasar U, Basci N E, Bozkurt A, Kayaalp S O, Zilelioglu O
机构信息
Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
出版信息
Eye (Lond). 1999 Oct;13 ( Pt 5):656-9. doi: 10.1038/eye.1999.178.
PURPOSE
To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects.
METHODS
Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography.
RESULTS
Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 +/- 0.04 microgram/ml (mean +/- SEM) and 1.34 +/- 0.14 micrograms/ml respectively (p < 0.0001).
CONCLUSION
Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.
目的
评估同一受试者局部应用0.3%环丙沙星和0.3%氧氟沙星后的房水浓度。
方法
32例双侧白内障患者在每次白内障摘除术前，一只眼局部应用0.3%环丙沙星，另一只眼局部应用0.3%氧氟沙星。滴眼液重复滴注6小时。采集房水样本，采用我们最初描述的高效液相色谱法测定药物浓度。
结果
房水中环丙沙星和氧氟沙星的平均浓度分别为0.33±0.04微克/毫升（平均值±标准误）和1.34±0.14微克/毫升（p<0.0001）。
结论
在同一受试者中，房水中氧氟沙星的浓度是环丙沙星浓度的4倍。
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