左氧氟沙星在人房水中的角膜穿透性：与环丙沙星的比较。
Corneal penetration of levofloxacin into the human aqueous humour: a comparison with ciprofloxacin.
作者信息
Colin Joseph, Simonpoli Sylvie, Geldsetzer Klaus, Ropo Auli
机构信息
Department of Ophthalmology, Hôpital Pellegrin, Bordeaux, France.
出版信息
Acta Ophthalmol Scand. 2003 Dec;81(6):611-3. doi: 10.1111/j.1395-3907.2003.00173.x.
PURPOSE
To compare aqueous humour levels of levofloxacin and ciprofloxacin following topical application to patients scheduled for cataract surgery.
METHODS
A total of 59 patients undergoing cataract surgery were randomly assigned to topical treatment with either levofloxacin 0.5% or ciprofloxacin 0.3% eye drops, at one drop every 15 min for four doses immediately prior to surgery. Aqueous humour samples were collected by paracentesis and analysed for drug content.
RESULTS
The (geometric) mean aqueous humour concentration of levofloxacin was 0.728 microg/ml; that of ciprofloxacin was 0.080 microg/ml.
CONCLUSIONS
Levofloxacin achieves 9.1 times the aqueous humour concentration of ciprofloxacin. It could be considered a better choice than ofloxacin or ciprofloxacin for topical ophthalmic use.
目的
比较计划接受白内障手术的患者局部应用左氧氟沙星和环丙沙星后房水内的药物水平。
方法
总共59例接受白内障手术的患者被随机分配接受局部治疗，一组使用0.5%左氧氟沙星滴眼液，另一组使用0.3%环丙沙星滴眼液，在手术前立即每15分钟滴一滴，共四剂。通过前房穿刺采集房水样本并分析药物含量。
结果
左氧氟沙星的（几何）平均房水浓度为0.728微克/毫升；环丙沙星的为0.080微克/毫升。
结论
左氧氟沙星的房水浓度是环丙沙星的9.1倍。对于局部眼科应用，它可被认为是比氧氟沙星或环丙沙星更好的选择。
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