Ruiz-Tovar M, Pollán-Santamaría M, López-Abente G
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España.
Rev Neurol. 1999;29(9):889-91.
Increasing incidences or mortality rates from brain malignant tumors have been reported in several countries.
This is a review of the studies published by the Cancer Epidemiology Unit of Carlos III Health Institute on incidence and mortality from these tumors in adults and children in Spain.
During the period 1952-1986 mortality in adults has increased in both sexes. An ascending effect in cohorts born up to 1920 is detected, probably due to improvements in diagnosis and registration. A positive, progressive, cohort effect in males born post-1920 was detected probably because of a true increase in incidence of brain glioma or brain metastases. The incidence analysis in Navarre and Zaragoza (two Spanish provinces with population-based Cancer Registries working for more than 20 years) shows an increase in all age groups rates, reater among the older age groups. In Navarre we detected a decrease cohort effect in 1978-82 and 1988-91. A more than 50% decrease in mortality is observed among children and adolescent, probably due to treatment improvements. Great geographic differences have been observed in mortality, associated to industry development. Incidence in children, according to the Navarre and Zaragoza Registries, has increased in part due to better diagnostic methods. Incidence is 75% greater in Navarre than in Zaragoza.
据报道，在一些国家，脑恶性肿瘤的发病率或死亡率呈上升趋势。
本文回顾了卡洛斯三世健康研究所癌症流行病学部门发表的关于西班牙成人和儿童这些肿瘤发病率和死亡率的研究。
在1952年至1986年期间，成人死亡率在两性中均有所上升。在1920年以前出生的队列中发现了一种上升效应，这可能是由于诊断和登记的改善。在1920年以后出生的男性中发现了一种积极的、渐进的队列效应，这可能是由于脑胶质瘤或脑转移瘤发病率的真正增加。在纳瓦拉和萨拉戈萨（西班牙的两个省份，其基于人群的癌症登记处已运作20多年）的发病率分析显示，所有年龄组的发病率都有所上升，在老年组中上升幅度更大。在纳瓦拉，我们在1978 - 82年和1988 - 91年发现了队列效应下降。儿童和青少年的死亡率下降了50%以上，这可能是由于治疗的改善。在死亡率方面观察到了与工业发展相关的巨大地理差异。根据纳瓦拉和萨拉戈萨登记处的数据，儿童发病率有所上升，部分原因是诊断方法的改进。纳瓦拉的发病率比萨拉戈萨高75%。
