Miyazaki H, Hayashi K
Department of Systems and Human Science, Graduate School of Engineering Science, Osaka University, Japan.
Med Biol Eng Comput. 1999 Jul;37(4):530-6. doi: 10.1007/BF02513342.
Mechanical properties of living endothelial cells in the abdominal aortas and in the medial and lateral wall of aortic bifurcations obtained from rabbits were determined by means of an atomic force microscope (AFM), focusing on the locational differences. Force (F)-indentation (delta) curves of the cells were expressed by an exponential function: F = a(exp(b delta)-1), where a and b are constants. The parameters b and c(= ab) represent the rate of modulus change and initial modulus, respectively. The slope of F-delta curves a and the parameter c were higher in the medial wall than in the other sites, which is attributable to abundant stress fibres in endothelial cells in the medial wall. There were no differences in the parameter b among the three locations. These results indicate that endothelial cells are stiffer in the medial wall of aortic bifurcation than in the other regions.
通过原子力显微镜（AFM）测定了从兔身上获取的腹主动脉以及主动脉分叉处内侧壁和外侧壁中活内皮细胞的力学性能，重点关注位置差异。细胞的力（F）-压痕（δ）曲线用指数函数表示：F = a(exp(bδ)-1)，其中a和b为常数。参数b和c（= ab）分别代表模量变化率和初始模量。F-δ曲线的斜率a和参数c在内侧壁比在其他部位更高，这归因于内侧壁内皮细胞中丰富的应力纤维。三个位置之间参数b没有差异。这些结果表明，主动脉分叉处内侧壁的内皮细胞比其他区域更硬。
