Deleu D, Hanssens Y
Sultan Qaboos University, Al-Khod, Sultanate of Oman.
J Toxicol Clin Toxicol. 2000;38(1):37-41. doi: 10.1081/clt-100100913.
A 21-year-old man who had sniffed toluene since the age of 13 presented with a 4-year history of progressive cerebellar dysfunction and visual deterioration. The patient's condition did not improve despite 5 months of abstinence. Magnetic resonance imaging revealed cerebral atrophy and hypointensity signals in the white matter and bilaterally in the globus pallidus, thalamus, red nucleus, and substantia nigra. Amantadine hydrochloride therapy (100 mg/d, then 200 mg/d) resulted in dramatic improvement of his cerebellar and visual symptoms.
一名自13岁起就吸食甲苯的21岁男性，出现了4年的进行性小脑功能障碍和视力减退病史。尽管戒断了5个月，患者的病情仍未改善。磁共振成像显示脑萎缩，白质以及双侧苍白球、丘脑、红核和黑质出现低信号。盐酸金刚烷胺治疗（100毫克/天，然后200毫克/天）使他的小脑和视觉症状得到显著改善。
