百里醌对神经毒性剂的解毒作用。
Antidotal effects of thymoquinone against neurotoxic agents.
作者信息
Sanati Ali Rajabpour, Farkhondeh Tahereh, Samarghandian Saeed
机构信息
Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Innovative Medical Research Center, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
出版信息
Interdiscip Toxicol. 2018 Aug;11(2):122-128. doi: 10.2478/intox-2018-0008. Epub 2019 Mar 2.
Several plants which contain the active component thymoquinone (TQ) have been traditionally used in herbal medicine to treat various diseases. Several studies indicated the protective effects of TQ against neurotoxic agents. The present study was aimed to highlight the protective effects of TQ against neurotoxic agents. For this reason, the literature from 1998 to 2017 regarding the protective effects of TQ against neurotoxic agents and their involvement mechanisms has been studied. The present review suggests the protective effects of TQ against neurotoxic agents in experimental models. More clinical trial studies are however needed to confirm the antidotal effects of TQ in human intoxication.
几种含有活性成分百里醌（TQ）的植物传统上被用于草药治疗各种疾病。多项研究表明TQ对神经毒性剂具有保护作用。本研究旨在突出TQ对神经毒性剂的保护作用。因此，对1998年至2017年有关TQ对神经毒性剂的保护作用及其作用机制的文献进行了研究。本综述表明TQ在实验模型中对神经毒性剂具有保护作用。然而，需要更多的临床试验研究来证实TQ对人体中毒的解毒作用。
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