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百里醌对神经毒性剂的解毒作用。

Antidotal effects of thymoquinone against neurotoxic agents.

作者信息

Sanati Ali Rajabpour, Farkhondeh Tahereh, Samarghandian Saeed

机构信息

Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

Innovative Medical Research Center, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

出版信息

Interdiscip Toxicol. 2018 Aug;11(2):122-128. doi: 10.2478/intox-2018-0008. Epub 2019 Mar 2.

DOI:10.2478/intox-2018-0008
PMID:31719783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6829686/
Abstract

Several plants which contain the active component thymoquinone (TQ) have been traditionally used in herbal medicine to treat various diseases. Several studies indicated the protective effects of TQ against neurotoxic agents. The present study was aimed to highlight the protective effects of TQ against neurotoxic agents. For this reason, the literature from 1998 to 2017 regarding the protective effects of TQ against neurotoxic agents and their involvement mechanisms has been studied. The present review suggests the protective effects of TQ against neurotoxic agents in experimental models. More clinical trial studies are however needed to confirm the antidotal effects of TQ in human intoxication.

摘要

几种含有活性成分百里醌（TQ）的植物传统上被用于草药治疗各种疾病。多项研究表明TQ对神经毒性剂具有保护作用。本研究旨在突出TQ对神经毒性剂的保护作用。因此，对1998年至2017年有关TQ对神经毒性剂的保护作用及其作用机制的文献进行了研究。本综述表明TQ在实验模型中对神经毒性剂具有保护作用。然而，需要更多的临床试验研究来证实TQ对人体中毒的解毒作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2823/6829686/de0a7432a905/ITX-11-122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2823/6829686/de0a7432a905/ITX-11-122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2823/6829686/de0a7432a905/ITX-11-122-g001.jpg

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2
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Oncotarget. 2017 Apr 18;8(31):51907-51919. doi: 10.18632/oncotarget.17206. eCollection 2017 Aug 1.
3
Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain.
藏红花醛对大鼠脑固定化诱导氧化损伤的抗氧化作用。
Neurosci Lett. 2017 Oct 17;659:26-32. doi: 10.1016/j.neulet.2017.08.065. Epub 2017 Sep 1.
4
Riboflavin Responsive Mitochondrial Dysfunction in Neurodegenerative Diseases.神经退行性疾病中的核黄素反应性线粒体功能障碍
J Clin Med. 2017 May 5;6(5):52. doi: 10.3390/jcm6050052.
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Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats.鼠尾草酚对慢性应激诱导的大鼠脑氧化应激损伤的保护作用。
BMC Complement Altern Med. 2017 May 4;17(1):249. doi: 10.1186/s12906-017-1753-9.
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The effects of thymoquinone on hippocampal cytokine level, brain oxidative stress status and memory deficits induced by lipopolysaccharide in rats.胸腺醌对大鼠脂多糖诱导的海马细胞因子水平、脑氧化应激状态及记忆缺陷的影响。
Cytokine. 2017 Aug;96:173-184. doi: 10.1016/j.cyto.2017.04.015. Epub 2017 Apr 19.
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Pharm Biol. 2017 Dec;55(1):1171-1176. doi: 10.1080/13880209.2017.1288262.
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A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice.对苯二酚对戊四氮诱导的小鼠点燃效应和认知障碍改善作用的潜在机制。
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