Goldstein N S, Czako P, Neill J S
Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Mod Pathol. 2000 Feb;13(2):123-30. doi: 10.1038/modpathol.3880023.
Most studies that have examined minimally invasive, encapsulated, follicular carcinoma (FC) or Hurthle cell carcinomas (HCs) have contained only a few metastatic neoplasms. We studied 34 patients with a single, minimally invasive, metastatic FC or HC and compared them with 38 patients with similar, nonmetastatic FCs or HCs. The numbers of incomplete capsular penetration (neoplasm into but not through the capsule), complete capsular penetration (neoplasm through the capsule), and vascular invasion foci were quantified. The median number (three), range, and distribution of complete capsular penetration and vascular invasion foci were similar in the nonmetastatic and metastatic carcinomas. All of the metastatic FCs and HCs had at least one vascular invasion or complete capsular penetration focus. Sixty-two percent of the metastatic carcinomas had two to four complete capsular penetration foci, and 60% had two to four vascular invasion foci. Two metastatic neoplasms had incomplete capsular penetration but had one and two vascular invasion foci, respectively. One tumor had no vascular invasion but had four complete capsular penetration foci. No metastatic neoplasms had incomplete capsular penetration only. There were no differences in the number of vascular invasion or complete capsular penetration foci between metastatic and nonmetastatic FCs and HCs and between metastatic FCs and HCs. Most metastatic neoplasms had vascular space invasion and complete capsular penetration. The number of complete capsular penetration or vascular invasion foci was not associated with the initial site of metastasis or the interval between the surgery and the metastasis.
大多数对微创性、包膜内滤泡癌（FC）或许特耳细胞癌（HC）进行研究的文献仅纳入了少数转移性肿瘤。我们研究了34例单发、微创性转移性FC或HC患者，并将其与38例具有相似情况的非转移性FC或HC患者进行比较。对包膜穿透不完全（肿瘤侵入包膜但未穿透）、包膜穿透完全（肿瘤穿透包膜）和血管侵犯灶的数量进行了量化。非转移性癌和转移性癌中包膜穿透完全和血管侵犯灶的中位数（三个）、范围及分布相似。所有转移性FC和HC均至少有一个血管侵犯或包膜穿透完全灶。62%的转移性癌有两到四个包膜穿透完全灶，60%有两到四个血管侵犯灶。两个转移性肿瘤包膜穿透不完全，但分别有一个和两个血管侵犯灶。一个肿瘤无血管侵犯，但有四个包膜穿透完全灶。没有转移性肿瘤仅有包膜穿透不完全的情况。转移性和非转移性FC及HC之间，以及转移性FC和HC之间，血管侵犯或包膜穿透完全灶的数量没有差异。大多数转移性肿瘤有血管腔隙侵犯和包膜穿透完全。包膜穿透完全或血管侵犯灶的数量与转移的初始部位或手术与转移之间的间隔无关。
