Mitchell A D, Ayoub K, Mangham D C, Grimer R J, Carter S R, Tillman R M
Royal Orthopaedic Hospital Oncology, Service, Woodlands, Northfield, Birmingham, UK.
J Bone Joint Surg Br. 2000 Jan;82(1):55-61. doi: 10.1302/0301-620x.82b1.9020.
Dedifferentiated chondrosarcoma is a rare, highly malignant variant of chondrosarcoma in which a high-grade spindle-cell sarcoma coexists with a lower-grade chondroid tumour. We have reviewed our experience with this neoplasm in 22 patients, all of whom were treated using modern oncological principles of planned resection and chemotherapy. Despite this the median survival was under nine months and only 18% were alive at five years. Those patients who received chemotherapy, and in whom wide margins of excision were achieved at operation, did best. It is essential to have an accurate preoperative diagnosis in order to plan treatment which may offer a better prospect of cure.
去分化软骨肉瘤是软骨肉瘤中一种罕见的、高度恶性的变异型，其中高级别梭形细胞肉瘤与低级别软骨样肿瘤共存。我们回顾了22例该肿瘤患者的治疗经验，所有患者均采用现代肿瘤学的计划性切除和化疗原则进行治疗。尽管如此，中位生存期仍不足9个月，5年生存率仅为18%。那些接受化疗且手术切缘达到广泛切除的患者预后最佳。为了制定可能提供更好治愈前景的治疗方案，准确的术前诊断至关重要。
