Matowicka-Karna J, Mantur M, Darewicz B, Kemona H
Institute of Laboratory Diagnostics, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1999;44:55-63.
Embolization consists in the occlusion of renal artery and its ramifications, which induces acute renal infarction. Renal artery embolization, causing necrosis, stimulates cellular reactions within and around the neoplasm. The interaction of neoplastic cells with blood platelets is of great importance in the development of neoplastic disease. Neoplastic cells exert a stimulatory effect on blood platelets. During activation, platelets change in shape and secrete certain substances. The aim of the present study was to evaluate morphological parameters of blood platelets in renal cancer patients before and after renal artery embolization. 45 patients suffering from renal cancer were examined (22 women and 23 men) before and after embolization. Diagnosis was established basing on the patients' history, clinical picture, and ultrasonographic, urographic and angiographic examinations. Tumour advancement was defined as T2 and T3. The study has demonstrated that embolization leads to an increase in platelet count and in the percentage of "megathrombocytes". The changes observed in the study may indirectly testify to the involvement of the thrombopoietic system in the course of neoplastic disease.
栓塞术是指闭塞肾动脉及其分支，从而引发急性肾梗死。肾动脉栓塞导致坏死，刺激肿瘤内部及周围的细胞反应。肿瘤细胞与血小板的相互作用在肿瘤疾病的发展过程中至关重要。肿瘤细胞对血小板具有刺激作用。在激活过程中，血小板会改变形状并分泌某些物质。本研究的目的是评估肾癌患者肾动脉栓塞前后血小板的形态学参数。对45例肾癌患者（22例女性和23例男性）在栓塞前后进行了检查。根据患者的病史、临床表现以及超声、尿路造影和血管造影检查来确诊。肿瘤进展程度定义为T2和T3。研究表明，栓塞会导致血小板计数及“巨型血小板”百分比增加。该研究中观察到的变化可能间接证明了血小板生成系统参与了肿瘤疾病的进程。
