MAGE 3基因产物在头颈部鳞状细胞癌中的表达。
Expression of the MAGE 3 gene product in squamous cell carcinomas of the head and neck.
作者信息
Lee K D, Chang H K, Jo Y K, Kim B S, Lee B H, Lee Y W, Lee H K, Huh M H, Min Y G, Spagnoli G C, Yu T H
机构信息
Department of Otolaryngology, Kosin University College of Medicine, Pusan, Korea.
出版信息
Anticancer Res. 1999 Nov-Dec;19(6B):5037-42.
BACKGROUND
The melanoma antigen (MAGE) 3 gene may be a useful tumor specific marker since it is expressed in a variety of cancers.
MATERIALS & METHOD: The expression and intracellular location of MAGE 3 gene product were investigated in 40 squamous cell carcinomas, 2 tumor lines, 20 benign diseases, and 20 normal tissues of the head and neck. Immunohistochemical staining with anti-MAGE 3 mAb 57B was conducted from fresh frozen specimens. Correlations between MAGE 3 expression and clinicopathological parameters were also evaluated.
RESULTS
The MAGE 3 gene product was detected in squamous cell carcinomas (18/40, 45%) and in tumor cell lines (2/2, 100%), but not in benign diseases and normal tissues. No significant correlation was drawn between MAGE 3 expression and clinical parameters including clinical stages and metastasis.
CONCLUSION
These results show MAGE 3 antigen could represent a potential target for immunotherapy in head and neck squamous cell carcinomas.
背景
黑色素瘤抗原（MAGE）3基因可能是一种有用的肿瘤特异性标志物，因为它在多种癌症中表达。
材料与方法
研究了40例头颈部鳞状细胞癌、2种肿瘤细胞系、20种良性疾病以及20种头颈部正常组织中MAGE 3基因产物的表达及细胞内定位。使用抗MAGE 3单克隆抗体57B对新鲜冷冻标本进行免疫组织化学染色。还评估了MAGE 3表达与临床病理参数之间的相关性。
结果
在鳞状细胞癌（18/40，45%）和肿瘤细胞系（2/2，100%）中检测到MAGE 3基因产物，但在良性疾病和正常组织中未检测到。MAGE 3表达与包括临床分期和转移在内的临床参数之间未发现显著相关性。
结论
这些结果表明，MAGE 3抗原可能是头颈部鳞状细胞癌免疫治疗的潜在靶点。
Zotero 插件