Natsugoe S, Tokuda K, Shimada M, Kumanohoso T, Baba M, Takao S, Tabata M, Nakamura K, Yoshizawa H, Aikou T
First Department of Surgery, Kagoshima University School of Medicine, Japan.
Anticancer Res. 1999 Nov-Dec;19(6B):5163-7.
We observed the morphological changes in microspheres containing cisplatin (CDDP) embedded in poly-d,l,-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS). The in vitro release of CDDP from CDDP-PPMS continued for more than four weeks. Scanning electron microscopy revealed that though the particles of CDDP-PPMS were spherical and superficially smooth, small pores with a superficial irregularity appeared six months later. CDDP-PPMS particles were found in the stomata of the omentum after intraperitoneal administration. When CDDP-PPMS was administered after Yoshida sarcoma cells were intraperitoneally transplanted, CDDP-PPMS was observed histologically in the necrotic tissues of the omentum. These experimental results confirmed the release of CDDP from CDDP-PPMS and the histological efficacy of CDDP-PPMS in the omentum against peritoneal metastasis.
我们观察了聚-d，l-乳酸（PLA）和聚乙醇酸（CDDP-PPMS）包载顺铂（CDDP）的微球的形态变化。CDDP从CDDP-PPMS的体外释放持续了四周以上。扫描电子显微镜显示，尽管CDDP-PPMS颗粒呈球形且表面光滑，但六个月后出现了表面不规则的小孔。腹腔给药后，在大网膜的气孔中发现了CDDP-PPMS颗粒。当在吉田肉瘤细胞腹腔移植后给予CDDP-PPMS时，在组织学上观察到CDDP-PPMS存在于大网膜的坏死组织中。这些实验结果证实了CDDP从CDDP-PPMS中的释放以及CDDP-PPMS在大网膜中对腹膜转移的组织学疗效。
