Kammerer C, Czermak I, Getoff N, Kodym R
Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, Vienna, Austria.
Anticancer Res. 1999 Nov-Dec;19(6B):5319-21.
Using E.coli bacteria (AB 1157) and leukemia cells (HL 60) as a model for in vitro studies it was established that the efficiency of mitomycin C (MMC) can be influenced in the presence of antioxidant vitamins. This synergistic effect of the vitamins C, E-acetate and beta-carotene on MMC activity is rather strong for E.coli bacteria under irradiation (15 and 50 Gy) in the presence of air. Vitamin C contributes more efficiently to the MMC-activity in leukemia cells than the other two vitamins. The effect is explained by a cascade electron transfer process from the vitamins to MMC, where vitamin C is acting as a major electron source. These results might be of importance in cancer therapy.
以大肠杆菌（AB 1157）和白血病细胞（HL 60）作为体外研究模型，研究发现抗氧化维生素的存在会影响丝裂霉素C（MMC）的功效。在有空气存在的情况下，维生素C、维生素E醋酸酯和β-胡萝卜素对MMC活性的这种协同作用，对于受辐照（15和50戈瑞）的大肠杆菌而言相当显著。在白血病细胞中，维生素C对MMC活性的贡献比其他两种维生素更有效。这种效应可通过从维生素到MMC的级联电子转移过程来解释，其中维生素C作为主要电子源。这些结果可能对癌症治疗具有重要意义。
