Ylisirniö S, Sassi M L, Risteli J, Turpeenniemi-Hujanen T, Jukkola A
Department of Oncology, Oulu University Hospital, Finland.
Anticancer Res. 1999 Nov-Dec;19(6C):5577-81.
We investigated the prognostic value of the serum markers of type I collagen synthesis (PINP and PICP) and degradation (ICTP and CrossLaps) in 143 lung cancer patients with a local or locally advanced disease or a metastatic disease. The mean values of ICTP, CrossLaps, PINP and PICP were significantly higher in patients with bone metastases than in those without metastases or with only soft tissue metastases. The patients with ICTP < or = 5.0 micrograms/l or CrossLaps < or = 5000 pmol/l had a better prognosis. The histopathological type, the site of metastases or the stage of the disease had no influence on these results. In multivariate regression analysis, both ICTP and CrossLaps in contrast to PINP or PICP, were prognostic factors for poor survival in lung cancer patients. ICTP, CrossLaps, sedimentation rate, hemoglobin and AFOS reached separately weaker, but statistically significant values as predictors of survival with stage and operation.
我们研究了143例局部或局部晚期疾病或转移性疾病的肺癌患者中I型胶原合成（PINP和PICP）及降解（ICTP和CrossLaps）的血清标志物的预后价值。骨转移患者的ICTP、CrossLaps、PINP和PICP的平均值显著高于无转移或仅有软组织转移的患者。ICTP≤5.0微克/升或CrossLaps≤5000皮摩尔/升的患者预后较好。组织病理学类型、转移部位或疾病分期对这些结果无影响。在多变量回归分析中，与PINP或PICP相比，ICTP和CrossLaps均是肺癌患者生存不良的预后因素。ICTP、CrossLaps、血沉、血红蛋白和AFOS分别作为与分期和手术相关的生存预测指标，其预测价值较弱，但具有统计学意义。
