Kobayashi Y, Tokue A
Department of Urology, Jichi Medical School.
Nihon Rinsho. 1998 Aug;56(8):2072-6.
PICP and PINP are considered markers of bone formation, and ICTP is considered to be a marker of bone resorption. We measured these three markers as indicators of bone metastasis of prostatic cancer, and assessed their clinical usefulness. Serum PICP, PINP and ICTP were significant higher in patients with bone metastasis than localized cancer or controlled bone metastasis. Serum PSA increased initially with the LH-RH agonist during the course of bone metastasis. All these markers were subsequently observed to increase. Change in PICP of patients with bone metastasis was slight compared to PINP during endocrine treatment. Serum PICP, PINP and ICTP reflect the extent of metastasis in bone and are useful for monitoring the response of this condition to therapy.
血清I型前胶原羧基端前肽（PICP）和I型前胶原氨基端前肽（PINP）被视为骨形成标志物，而血清I型胶原羧基端肽（ICTP）被视为骨吸收标志物。我们检测这三种标志物作为前列腺癌骨转移的指标，并评估其临床实用性。骨转移患者的血清PICP、PINP和ICTP显著高于局限性癌或可控性骨转移患者。在骨转移过程中，血清前列腺特异性抗原（PSA）最初随促性腺激素释放激素（LH-RH）激动剂升高，随后观察到所有这些标志物均升高。在内分泌治疗期间，骨转移患者的PICP变化与PINP相比轻微。血清PICP、PINP和ICTP反映骨转移程度，有助于监测该疾病对治疗的反应。
