在一名异基因骨髓移植后复发的慢性粒细胞白血病患者中，通过分次剂量递增的供体白细胞输注诱导分子缓解，且未发生移植物抗宿主病。
Molecular remission induced by fractionated dose-escalating donor leukocyte infusion without graft-versus-host disease in a patient with chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation.
作者信息
Inai K, Wano Y, Yamamoto S, Ikebata Y, Iwasaki H, Tsutani H, Naiki H, Ueda T
机构信息
First Department of Intemal Medicine, Fukui Medical University, School of Medicine, Japan.
出版信息
Anticancer Res. 1999 Nov-Dec;19(6C):5631-4.
A 39-year-old male with CML who relapsed 5 years and 8 months after allogeneic bone marrow transplantation achieved complete molecular remission following fractionated dose-escalating donor leukocyte infusions. Acute or chronic graft-versus-host disease (GVHD) did not occur and the patient remained asymptomatic throughout treatment. Since no prophylaxis against GVHD was administered, this case indicated that the graft-versus-leukemia effect is entirely separate from GVHD in certain conditions.
一名39岁的慢性粒细胞白血病男性患者，在异基因骨髓移植后5年零8个月复发，在接受分次剂量递增的供体白细胞输注后实现了完全分子缓解。未发生急性或慢性移植物抗宿主病（GVHD），且患者在整个治疗过程中均无症状。由于未进行预防GVHD的治疗，该病例表明在某些情况下，移植物抗白血病效应与GVHD完全无关。
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