• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在一名异基因骨髓移植后复发的慢性粒细胞白血病患者中，通过分次剂量递增的供体白细胞输注诱导分子缓解，且未发生移植物抗宿主病。

Molecular remission induced by fractionated dose-escalating donor leukocyte infusion without graft-versus-host disease in a patient with chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation.

作者信息

Inai K, Wano Y, Yamamoto S, Ikebata Y, Iwasaki H, Tsutani H, Naiki H, Ueda T

机构信息

First Department of Intemal Medicine, Fukui Medical University, School of Medicine, Japan.

出版信息

Anticancer Res. 1999 Nov-Dec;19(6C):5631-4.

PMID:10697631
Abstract

A 39-year-old male with CML who relapsed 5 years and 8 months after allogeneic bone marrow transplantation achieved complete molecular remission following fractionated dose-escalating donor leukocyte infusions. Acute or chronic graft-versus-host disease (GVHD) did not occur and the patient remained asymptomatic throughout treatment. Since no prophylaxis against GVHD was administered, this case indicated that the graft-versus-leukemia effect is entirely separate from GVHD in certain conditions.

摘要

一名39岁的慢性粒细胞白血病男性患者，在异基因骨髓移植后5年零8个月复发，在接受分次剂量递增的供体白细胞输注后实现了完全分子缓解。未发生急性或慢性移植物抗宿主病（GVHD），且患者在整个治疗过程中均无症状。由于未进行预防GVHD的治疗，该病例表明在某些情况下，移植物抗白血病效应与GVHD完全无关。

相似文献

1
Molecular remission induced by fractionated dose-escalating donor leukocyte infusion without graft-versus-host disease in a patient with chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation.在一名异基因骨髓移植后复发的慢性粒细胞白血病患者中，通过分次剂量递增的供体白细胞输注诱导分子缓解，且未发生移植物抗宿主病。
Anticancer Res. 1999 Nov-Dec;19(6C):5631-4.
2
Molecular remission occurring after donor leukocyte infusions for the treatment of relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation.供体白细胞输注用于治疗异基因骨髓移植后复发的慢性粒细胞白血病后出现的分子缓解。
Bone Marrow Transplant. 1992 Sep;10(3):301-4.
3
Donor leukocyte infusion for Japanese patients with relapsed leukemia after allogeneic bone marrow transplantation: lower incidence of acute graft-versus-host disease and improved outcome.供体白细胞输注用于日本异基因骨髓移植后复发白血病患者：急性移植物抗宿主病发生率较低且预后改善。
Bone Marrow Transplant. 2000 Oct;26(7):769-74. doi: 10.1038/sj.bmt.1702596.
4
[Successful treatment of recurrent chronic myelogenous leukemia in allogeneic marrow transplant recipient with the donor leukocyte transfusion, without induction of acute graft-versus-host disease].[供者白细胞输注成功治疗异基因骨髓移植受者复发性慢性粒细胞白血病，未诱发急性移植物抗宿主病]
Rinsho Ketsueki. 1995 Jul;36(7):677-81.
5
Achievement of complete cytogenetic remission after two very low-dose donor leucocyte infusions in a patient with extensive cGVHD relapsing in accelerated phase post allogeneic BMT for CML.一名慢性粒细胞白血病患者在异基因骨髓移植后加速期广泛慢性移植物抗宿主病复发，经两次极低剂量供体白细胞输注后实现完全细胞遗传学缓解。
Bone Marrow Transplant. 1998 May;21(9):955-6. doi: 10.1038/sj.bmt.1701195.
6
Donor leukocyte infusions for recurrent hematologic malignancies after allogeneic bone marrow transplantation: impact of infused and residual donor T cells.异基因骨髓移植后复发性血液系统恶性肿瘤的供体白细胞输注：输注的和残留的供体T细胞的影响
Bone Marrow Transplant. 1998 Dec;22(11):1057-63. doi: 10.1038/sj.bmt.1701496.
7
[Leukocyte transfusion as therapy of recurrent CML after allogenic bone marrow transplantation].
Beitr Infusionsther Transfusionsmed. 1994;32:276-80.
8
Alpha-interferon with very-low-dose donor lymphocyte infusion for hematologic or cytogenetic relapse of chronic myeloid leukemia induces rapid and durable complete remissions and is associated with acceptable graft-versus-host disease.α干扰素联合极低剂量供体淋巴细胞输注治疗慢性髓性白血病血液学或细胞遗传学复发可诱导快速且持久的完全缓解，并与可接受的移植物抗宿主病相关。
Biol Blood Marrow Transplant. 2004 Mar;10(3):204-12. doi: 10.1016/j.bbmt.2003.11.003.
9
Eradication of residual bcr-abl-positive clones by inducing graft-versus-host disease after allogeneic stem cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.在费城染色体阳性急性淋巴细胞白血病患者中，通过诱导异基因干细胞移植后的移植物抗宿主病来清除残留的bcr-abl阳性克隆。
Bone Marrow Transplant. 2002 Jan;29(1):63-6. doi: 10.1038/sj.bmt.1703318.
10
[Donor leukocyte transfusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation].[供体白细胞输注作为异基因骨髓移植后复发慢性粒细胞白血病的治疗方法]
Rinsho Ketsueki. 1998 Jun;39(6):409-15.

引用本文的文献

1
Successful eradication of residual bcr-abl-positive clones by donor leukocyte transfusion in a patient with philadelphia chromosome-positive acute lymphoblastic leukemia after peripheral blood stem cell transplantation.在一名费城染色体阳性急性淋巴细胞白血病患者外周血干细胞移植后，通过供体白细胞输注成功根除残留的bcr-abl阳性克隆。
Int J Hematol. 2001 Oct;74(3):354-6. doi: 10.1007/BF02982075.