Drobyski W R, Roth M S, Thibodeau S N, Gottschall J L
Department of Medicine, Medical College of Wisconsin, Milwaukee.
Bone Marrow Transplant. 1992 Sep;10(3):301-4.
Donor leukocyte infusions were administered to a patient who had relapsed with chronic myelogenous leukemia after having failed two successive HLA-matched allogeneic bone marrow transplants. Serial cytogenetic, restriction fragment length polymorphism, and polymerase chain reaction studies of the patient's marrow and blood after receiving donor leukocyte infusions revealed disappearance of the leukemic clone and the establishment of complete donor chimerism. An antileukemic response in this patient occurred initially in the absence of clinically evident graft-versus-host disease (GVHD), but complete eradication of the leukemic clone did not occur until after the onset of GVHD. The patient is now 48 weeks post infusion and remains in complete remission. This case demonstrates that leukocyte infusions are an effective form of adoptive immunotherapy which can result in a sustained molecular remission.
在经历两次连续的人类白细胞抗原（HLA）匹配的异基因骨髓移植失败后复发慢性粒细胞白血病的患者接受了供体白细胞输注。接受供体白细胞输注后，对该患者的骨髓和血液进行系列细胞遗传学、限制性片段长度多态性和聚合酶链反应研究，结果显示白血病克隆消失，完全供体嵌合体得以建立。该患者最初在无临床明显移植物抗宿主病（GVHD）的情况下出现抗白血病反应，但直到GVHD发生后白血病克隆才被完全清除。该患者目前处于输注后48周，仍处于完全缓解状态。此病例表明白细胞输注是一种有效的过继性免疫治疗形式，可导致持续的分子缓解。
