Rahman S L, Mahendra P, Nacheva E, Sinclair P, Arno J, Marcus R E
Bone Marrow Transplant Unit, Addenbrooke's NHS Trust, Cambridge, UK.
Bone Marrow Transplant. 1998 May;21(9):955-6. doi: 10.1038/sj.bmt.1701195.
We report the case of a 55-year-old female who despite having developed extensive chronic graft-versus-host disease (GVHD), relapsed 35 months after a T cell-replete sibling donor bone marrow transplant for Philadelphia-positive chronic myeloid leukaemia (Ph CML). She achieved complete cytogenetic remission after discontinuation of cyclosporin A and administration of two low-dose donor leucocyte infusions (DLI 1 x 10(6) and 5 x 10(6) CD3+ cells/kg). Eighteen months after the first infusion she remains well and in complete cytogenetic remission with a normocellular marrow and no exacerbation of GVHD.
我们报告了一例55岁女性的病例，该患者尽管已发生广泛的慢性移植物抗宿主病（GVHD），但在接受T细胞充足的同胞供体骨髓移植治疗费城染色体阳性慢性髓性白血病（Ph CML）35个月后复发。停用环孢素A并给予两次低剂量供体白细胞输注（DLI 1×10⁶和5×10⁶ CD3⁺细胞/kg）后，她实现了完全细胞遗传学缓解。首次输注18个月后，她情况良好，处于完全细胞遗传学缓解状态，骨髓细胞正常，GVHD未加重。
