Ballou W R, Kester K E, Stoute J A, Heppner D G
Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
Parassitologia. 1999 Sep;41(1-3):403-8.
A safe and effective malaria vaccine will greatly facilitate efforts to control the global spread of malaria. This paper discusses the conceptual framework for developing malaria vaccines and some of the difficulties that the various approaches face. It emphasizes the role of pre-erythrocytic malaria vaccines, which are designed to protect against malaria infection, rather than simply prevent clinical disease. It describes recent encouraging results in human subjects with the RTS,S vaccine, a promising pre-erythrocytic malaria vaccine candidate.
一种安全有效的疟疾疫苗将极大地推动全球疟疾防控工作。本文讨论了开发疟疾疫苗的概念框架以及各种方法所面临的一些困难。它强调了针对疟原虫感染阶段的疟疾疫苗的作用，这类疫苗旨在预防疟疾感染，而非仅仅预防临床疾病。文中描述了在人体试验中使用RTS,S疫苗所取得的近期令人鼓舞的结果，RTS,S疫苗是一种很有前景的针对疟原虫感染阶段的疟疾疫苗候选产品。
