Feige K, Eser M W, Geissbühler U, Balestra E, Metzler K
Klinik für Wiederkäuer- und Pferdemedizin, Universität Zürich.
Schweiz Arch Tierheilkd. 2000 Feb;142(2):49-54.
Hirsutism was the most often observed symptom in horses with a pituitary gland tumor and was present in all 13 examined horses. Other symptoms were atrophy of muscles (n = 10), hyperhidrosis (n = 8), polyuria/polydipsia (n = 5), bulging or supraorbital fat (n = 3), polyphagia (n = 2), apathy (n = 2) and seizures (n = 2). Laminitis was the most frequently observed concurrent disease (n = 8). Hyperglycaemia (mean, 9.9 +/- 3.71 mmol/l) in 13 horses and glucosuria (median, 55 [range, 2-55] mmol/l) in 7 horses were the most important laboratory results. The dexamethasone suppression test was positive in all tested horses (n = 9) 20 h after administration of dexamethasone. The pituitary gland tumor was visible in every case underwent computed tomography (n = 7). From these results it can be concluded that a pituitary gland tumor can be suspected based on typical clinical signs. Hyperglycaemia and glucosuria support the preliminary diagnosis and a positive dexamethasone suppression test allows a final diagnosis.
多毛症是患有垂体肿瘤马匹中最常观察到的症状，在所有13匹接受检查的马匹中均有出现。其他症状包括肌肉萎缩（n = 10）、多汗症（n = 8）、多尿/多饮（n = 5）、眶上脂肪突出（n = 3）、多食（n = 2）、冷漠（n = 2）和癫痫发作（n = 2）。蹄叶炎是最常观察到的并发疾病（n = 8）。13匹马出现高血糖（平均，9.9 +/- 3.71 mmol/l），7匹马出现糖尿（中位数，55 [范围，2 - 55] mmol/l）是最重要的实验室检查结果。地塞米松抑制试验在所有受试马匹（n = 9）给予地塞米松20小时后均呈阳性。在每例接受计算机断层扫描的病例（n = 7）中均可见垂体肿瘤。从这些结果可以得出结论，基于典型的临床症状可怀疑垂体肿瘤。高血糖和糖尿支持初步诊断，而地塞米松抑制试验阳性则可确诊。
