van der Kolk J H, Wensing T, Kalsbeek H C, Breukink H J
Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht University, The Netherlands.
J Am Vet Med Assoc. 1995 Apr 1;206(7):1010-2.
Lipid metabolism was studied in 21 horses with hyperadrenocorticism. To be included in the study, horses had to have histologic evidence of a pars intermedia adenoma found at necropsy (n = 9), a baseline ACTH concentration greater than 400 pg/ml (n = 6), or a plasma cortisol concentration 2 hours after i.v. administration of 25 IU of ACTH greater than 413 nmol/L (n = 16). Mean +/- SD baseline plasma cortisol concentration was 338 +/- 261 nmol/L (n = 20), mean +/- SD plasma insulin concentration was 97 +/- 54 microU/ml (n = 15), mean +/- SD plasma beta-hydroxybutyrate concentration was 1.8 +/- 1.2 mg/dl (n = 21), and mean +/- SD plasma nonesterified fatty acids concentration was 6.2 +/- 6.4 mg/dl (n = 21). None of the horses had hyperlipemia. Compared with clinically normal horses, horses with hyperadrenocorticism had increased lipolysis and increased ketogenesis. It was concluded that cortisol cannot be the sole factor contributing to insulin resistance in horses with hyperadrenocorticism.
对21匹患有肾上腺皮质功能亢进的马的脂质代谢进行了研究。要纳入该研究，马匹必须在尸检时具有中间部腺瘤的组织学证据（n = 9）、基线促肾上腺皮质激素（ACTH）浓度大于400 pg/ml（n = 6），或静脉注射25 IU ACTH后2小时血浆皮质醇浓度大于413 nmol/L（n = 16）。平均±标准差基线血浆皮质醇浓度为338±261 nmol/L（n = 20），平均±标准差血浆胰岛素浓度为97±54 μU/ml（n = 15），平均±标准差血浆β-羟基丁酸浓度为1.8±1.2 mg/dl（n = 21），平均±标准差血浆非酯化脂肪酸浓度为6.2±6.4 mg/dl（n = 21）。所有马匹均无高脂血症。与临床正常的马匹相比，患有肾上腺皮质功能亢进的马匹脂肪分解增加，酮生成增加。得出的结论是，皮质醇不可能是导致患有肾上腺皮质功能亢进的马匹胰岛素抵抗的唯一因素。
