Horvath C J, Ames T R, Metz A L, Larson V L
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
J Am Vet Med Assoc. 1988 Feb 1;192(3):367-71.
Pituitary-dependent hyperadrenocorticism was diagnosed in a 14-year-old Arabian mare with chronic weight loss, hirsutism, polyuria, and polydipsia. The mare had a stress leukogram, glucosuria, and consistent hyperglycemia. Plasma glucose concentrations were resistant to suppression by insulin. Plasma cortisol concentrations were within normal limits, but did not respond to dexamethasone suppression and had an exaggerated response to ACTH stimulation. At necropsy, a chromophobe adenoma of the pars intermedia of the pituitary gland was found. The zona fasciculata of the adrenal cortex and the pancreatic islets of Langerhans were hypertrophied. An immunohistologic staining technique was used to demonstrate ACTH-containing neoplastic cells in the pituitary mass. These cells released ACTH and other peptides that initiated the chain of endocrinologic events leading to clinical disease.
一匹14岁的阿拉伯母马被诊断为垂体依赖性肾上腺皮质功能亢进，伴有慢性体重减轻、多毛症、多尿和烦渴。这匹母马有应激性白细胞象、糖尿和持续性高血糖。血浆葡萄糖浓度对胰岛素抑制有抵抗。血浆皮质醇浓度在正常范围内，但对地塞米松抑制无反应，对促肾上腺皮质激素（ACTH）刺激有过度反应。尸检时，发现垂体中间部有一个嫌色细胞瘤。肾上腺皮质束状带和胰岛肥大。采用免疫组织化学染色技术在垂体肿块中显示含ACTH的肿瘤细胞。这些细胞释放ACTH和其他肽，引发导致临床疾病的内分泌事件链。
