Baalbergen A, Janssen J W, van der Weiden R M
Department of Obstetrics and Gynecology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
Am J Reprod Immunol. 2000 Jan;43(1):21-4. doi: 10.1111/j.8755-8920.2000.430104.x.
To assess the relationship between serum cancer antigen (CA)-125 concentrations and the likelihood of pregnancy after in vitro fertilization/embryo transfer (IVF ET).
A prospective longitudinal follow-up study was conducted in 44 IVF patients receiving luteinizing hormone-releasing hormone (LHRH) suppression, followed by human menopausal gonadotrophin (hMG). There were no indications of endometriosis. Progesterone or human chorionic gonadotrophin (hCG) were given as luteal support. Serum samples were taken just before oocyte pick-up (OPU), 14 days after ET and, after the establishment of a clinical pregnancy, on day ET + 21. Samples were stored at -80 degrees C until analysis. CA-125 was measured using a commercially available enzyme immunoassay (IMx CA-125; Abbott, North Chicago, IL, USA). The signed rank (paired samples) and Wilcoxon tests were used for statistical analysis.
There were no differences in CA-125 concentrations at the time of OPU between pregnant (n = 18) and non-pregnant (n = 26) IVF patients. After OPU. the CA-125 concentrations rose both in pregnant (P<0.0001) and in non-pregnant (P <0.001) patients. This rise was greater after successful implantation, and 14 days after ET, higher CA-125 concentrations were found in the pregnant patients (P< 0.01).
Differences in serum CA-125 concentrations between pregnant and non-pregnant IVF patients appear to be related to the likelihood of successful implantation.
评估血清癌抗原（CA）-125浓度与体外受精/胚胎移植（IVF-ET）后妊娠可能性之间的关系。
对44例接受促黄体生成素释放激素（LHRH）抑制、随后使用人绝经期促性腺激素（hMG）的IVF患者进行了一项前瞻性纵向随访研究。没有子宫内膜异位症的迹象。给予黄体酮或人绒毛膜促性腺激素（hCG）作为黄体支持。在取卵前（OPU）、ET后14天以及临床妊娠确定后ET + 21天采集血清样本。样本保存在-80摄氏度直至分析。使用市售酶免疫测定法（IMx CA-125；美国伊利诺伊州北芝加哥雅培公司）测量CA-125。采用符号秩（配对样本）和Wilcoxon检验进行统计分析。
妊娠（n = 18）和未妊娠（n = 26）的IVF患者在OPU时CA-125浓度没有差异。OPU后，妊娠患者（P<0.0001）和未妊娠患者（P <0.001）的CA-125浓度均升高。成功着床后这种升高更大，并且在ET后14天，妊娠患者的CA-125浓度更高（P< 0.01）。
妊娠和未妊娠的IVF患者血清CA-125浓度的差异似乎与成功着床的可能性有关。
