Geva E, Amit A, Lerner-Geva L, Yaron Y, Daniel Y, Schwartz T, Azem F, Yovel I, Lessing J B
Fertilization Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Am J Reprod Immunol. 2000 Jan;43(1):36-40. doi: 10.1111/j.8755-8920.2000.430107.x.
The study was conducted to investigate the efficacy of prednisone and aspirin in autoantibody seropositive patients with repeated in vitro fertilization embryo transfer (IVF ET) failure.
The study group comprised 52 consecutive patients seropositive for non-organ-specific autoantibodies, i.e., anti-cardiolipin antibodies (ACA), anti-nuclear antibodies (ANA), anti-double-stranded (ds) DNA, rheumatoid factor (RF), and lupus anti-coagulant (LAC). These patients were treated with prednisone, 10 mg per day, and aspirin, 100 mg per day, starting 4 weeks before induction of ovulation in 52 IVF cycles.
The clinical pregnancy rate per cycle was 32.7% (17/52). No increased incidence of pregnancy complications, including premature labor, gestational diabetes mellitus, and pregnancy-induced hypertension, were found.
Combined treatment of prednisone for immunosuppression and aspirin as an anti-thrombotic agent, starting before ovulation induction, may improve pregnancy rate in autoantibody seropositive patients who have had repeated IVF-ET failures.
本研究旨在探讨泼尼松和阿司匹林对体外受精胚胎移植（IVF-ET）反复失败的自身抗体血清阳性患者的疗效。
研究组包括52例连续的非器官特异性自身抗体血清阳性患者，即抗心磷脂抗体（ACA）、抗核抗体（ANA）、抗双链（ds）DNA、类风湿因子（RF）和狼疮抗凝物（LAC）。在52个IVF周期中，这些患者在促排卵前4周开始接受泼尼松（每日10毫克）和阿司匹林（每日100毫克）治疗。
每个周期的临床妊娠率为32.7%（17/52）。未发现包括早产、妊娠期糖尿病和妊娠高血压在内的妊娠并发症发生率增加。
在促排卵前开始联合使用泼尼松进行免疫抑制和阿司匹林作为抗血栓药物治疗，可能会提高体外受精胚胎移植反复失败的自身抗体血清阳性患者的妊娠率。
