Geva E, Yaron Y, Lessing J B, Yovel I, Vardinon N, Burke M, Amit A
Tel Aviv Sourasky Medical Center, Israel.
Fertil Steril. 1994 Oct;62(4):802-6. doi: 10.1016/s0015-0282(16)57008-3.
To investigate the role of autoimmune factors as a possible cause for implantation failure as manifested by chemical pregnancy after IVF and ET.
Anticardiolipin, anti-double-stranded DNA (dsDNA), antinuclear antibody, lupus anticoagulant, and rheumatoid factor serum levels were examined in patients with chemical pregnancies and in matched controls.
An IVF unit, university-based IVF program.
The study group included 21 patients who had one or more chemical pregnancies and no deliveries. The control group consisted of 21 patients who had conceived and delivered after IVF-ET treatment, without any history of fetal wastage, matched for age, type and duration of infertility, and number of previous IVF cycles.
The incidence of circulating autoimmune antibodies in the study group was 33.3% (7/21). Three patients (14.2%) were positive for anticardiolipin, two (9.5%) were positive for antidsDNA, one (4.7%) for antinuclear factor, and one (4.7%) for rheumatoid factor. Autoimmune antibodies were not detected in any of the control group.
Autoimmunity may play a role in implantation failure in IVF-ET. Circulating autoimmune antibody screening is therefore recommended after chemical pregnancy.
探讨自身免疫因素作为体外受精-胚胎移植（IVF-ET）后生化妊娠所表现出的植入失败可能原因的作用。
检测生化妊娠患者及匹配对照组的抗心磷脂、抗双链DNA（dsDNA）、抗核抗体、狼疮抗凝物和类风湿因子的血清水平。
一所大学附属IVF中心的IVF单元。
研究组包括21例有一次或多次生化妊娠且未分娩的患者。对照组由21例IVF-ET治疗后受孕并分娩、无任何胎儿丢失史、年龄、不孕类型和持续时间以及既往IVF周期数相匹配的患者组成。
研究组循环自身免疫抗体的发生率为33.3%（7/21）。3例患者（14.2%）抗心磷脂阳性，2例（9.5%）抗dsDNA阳性，1例（4.7%）抗核因子阳性，1例（4.7%）类风湿因子阳性。对照组中未检测到自身免疫抗体。
自身免疫可能在IVF-ET植入失败中起作用。因此，建议在生化妊娠后进行循环自身免疫抗体筛查。
