Redfern R, Gill J E, Hadler M R
J Hyg (Lond). 1976 Dec;77(3):419-26. doi: 10.1017/s0022172400055807.
Feeding tests were carried out in the laboratory to evaluate WBA 8119 as a potential new rodenticide against wild common rats (Rattus norvegicus), ship rats (R. rattus) and house mice (Mus musculus). The results obtained are compared with data previously obtained for difenacoum, another member of the same series of 4-hydroxycoumarin anticoagulants. With warfarin-resistnat and non-resistant common rats, complete kills were obtained using a concentration of 0-0005% for 2 days, or 0-001% for 1 day: a 1-day test at 0-0005% killed 6 out of 10 and 17 out of 20 of the two types respectively. At 0-0005% complete kills of resistant ship rats were obtained after 2 days exposure and of resistant house mice after 1 day, but at 0-002% for 2 days there was some survival. Non-resistant ship rats and house mice were all killed after 2 days feeding on 0-002% bait. In 2-day palatability tests, R. norvegicus showed no significant aversion to the poison at 0-002% and 100% mortality was obtained. The poison was significantly unpalatable to R. rattus at 0-005% and to M. musculus at 0-005% and 0-002%, although with the last species these concentrations gave complete kills. It is concluded that WBA 8119 has greater activity than other known anticoagulants against the three commensal species examined. The laboratory results suggest that concentrations between 0-0005% and 0-002% would be suitable for field use against common rats, and between 0-002% and 0-005% for ship rats and house mice.
在实验室进行了喂养试验，以评估WBA 8119作为一种潜在的新型灭鼠剂对野生褐家鼠（Rattus norvegicus）、黑家鼠（R. rattus）和小家鼠（Mus musculus）的效果。将获得的结果与先前针对同一系列4-羟基香豆素抗凝剂的另一种成员敌鼠隆所获得的数据进行比较。对于对华法林耐药和不耐药的褐家鼠，使用0.0005%的浓度喂养2天或0.001%的浓度喂养1天可实现完全灭鼠：在0.0005%浓度下进行1天试验，两种类型的鼠分别有10只中的6只和20只中的17只被杀死。在0.0005%浓度下暴露2天后，耐药黑家鼠被完全灭鼠，耐药小家鼠在暴露1天后被完全灭鼠，但在0.002%浓度下喂养2天仍有部分存活。不耐药的黑家鼠和小家鼠在食用0.002%的诱饵2天后全部死亡。在为期2天的适口性试验中，褐家鼠对0.002%浓度的毒药没有明显厌恶，且死亡率达到100%。在0.005%浓度下，毒药对黑家鼠明显适口性差，在0.005%和0.002%浓度下对小家鼠明显适口性差，尽管对于最后一种鼠类，这些浓度可实现完全灭鼠。得出的结论是，WBA 8119对所检测的三种共生鼠类的活性比其他已知抗凝剂更强。实验室结果表明，0.0005%至0.002%的浓度适用于野外防治褐家鼠，0.002%至0.005%的浓度适用于防治黑家鼠和小家鼠。
