抗凝血灭鼠剂WBA 8119对耐华法林家鼠（小家鼠）封闭群体的试验。

Trials of the anticoagulants rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.).

作者信息

Rowe F P, Bradfield A

出版信息

J Hyg (Lond). 1976 Dec;77(3):427-31.

Abstract

The efficacy of the newly developed anticoagulant rodenticide WBA 8119 was evaluated against the house mouse (Mus musculus L.) using individual and family groups of warfarin-resistant animals. WBA 8119 at 0-002%, 0-005% and 0-01% in pinhead oatmeal bait gave complete kills of mice in 'no-choice' feeding tests carried out in cages and small pens. In replicated 21-day treatments on families of mice confined in larger pens and conditioned to feeding on plain foods, the overall mortalities obtained using the three formulated poison baits were 71/72, 62/63 and 57/57 respectively. The results of the WBA 8119 toxicity tests are considered in relation to previous findings on other anticoagulant rodenticides, particularly difenacoum. In equivalent tests, WBA 8119 performed better than difenacoum. The data thus support the laboratory findings that WBA 8119 is the most active anticoagulant so far tested for the control of warfarin-resistant house mice.

摘要

使用对华法林耐药的小家鼠（Mus musculus L.）个体和家族群体，对新开发的抗凝血灭鼠剂WBA 8119的药效进行了评估。在笼子和小围栏中进行的“无选择”喂食试验中，含0.002%、0.005%和0.01%WBA 8119的针头状燕麦诱饵能完全杀死小鼠。在对饲养于较大围栏中且习惯取食普通食物的小鼠家族进行的为期21天的重复处理中，使用这三种配制毒饵获得的总体死亡率分别为71/72、62/63和57/57。结合之前关于其他抗凝血灭鼠剂，特别是敌鼠隆的研究结果，对WBA 8119的毒性试验结果进行了考量。在等效试验中，WBA 8119的表现优于敌鼠隆。这些数据因此支持了实验室研究结果，即WBA 8119是迄今为止测试的用于控制对华法林耐药的家鼠的最有效的抗凝血剂。