作为灭鼠剂的敌鼠钠的实验室评估。
Laboratory evaluation of difenacoum as a rodenticide.
作者信息
Hadler M R, Redfern R, Rowe F P
出版信息
J Hyg (Lond). 1975 Jun;74(3):441-8. doi: 10.1017/s0022172400046957.
The efficacy of difenacoum as a new anticoagulant rodenticide was evaluated by blood coagulation studies and laboratory feeding tests using warfarin-resistant and non-resistant common rats (Rattus norvegicus), ship rats (R. rattus) and house mice (Mus musculus). Prothrombin assays indicated that the compound had as marked an activity with warfarin-resistant common rats as coumatetralyl had with non-resistant animals. Feeding tests confirmed that 0-005% would be a near-optimal concentration for field use, although there was some evidence of unpalatability. Results with ship rats and house mice were less favourable. Trials with enclosed colonies of warfarin-resistant mice confirmed the laboratory finding that although difenacoum was more effective than all other currently used anticoagulants, it was unlikely to give complete control. It is concluded that difenacoum is a valuable new rodenticide, especiaaly for controlling warfarin-resistant common rats.
通过凝血研究以及使用对华法林耐药和不耐药的普通大鼠（褐家鼠）、黑家鼠和小家鼠进行实验室喂养试验，评估了敌鼠钠盐作为一种新型抗凝血灭鼠剂的效果。凝血酶原测定表明，该化合物对耐药普通大鼠的活性与杀鼠迷对非耐药动物的活性一样显著。喂养试验证实，0.005%的浓度对于野外使用而言接近最佳浓度，尽管有一些适口性不佳的迹象。对黑家鼠和小家鼠的试验结果不太理想。对华法林耐药小鼠封闭群体的试验证实了实验室的发现，即尽管敌鼠钠盐比目前使用的所有其他抗凝血剂更有效，但不太可能实现完全控制。得出的结论是，敌鼠钠盐是一种有价值的新型灭鼠剂，特别是用于控制对华法林耐药的普通大鼠。
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